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Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 44 (2013); 94-99. https://doi.org/10.1016/j.pnpbp.2013.02.002
Mustapić, Maja; Presečki, Paola; Pivac, Nela; Mimica, Ninoslav; Hof, Patrick R.; Šimić, Goran; Folnegović-Šmalc, Vera; Muck-Šeler, Dorotea

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Mustapić, M., Presečki, P., Pivac, N., Mimica, N., Hof, P. R., Šimić, G. ... Muck Šeler, D. (2013). Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 44., 94-99. doi: 10.1016/j.pnpbp.2013.02.002

Mustapić, Maja, et al. "Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 44, 2013, str. 94-99. https://doi.org/10.1016/j.pnpbp.2013.02.002

Mustapić, Maja, Paola Presečki, Nela Pivac, Ninoslav Mimica, Patrick R. Hof, Goran Šimić, Vera Folnegović Šmalc i Dorotea Muck Šeler. "Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease." Progress in Neuro-Psychopharmacology and Biological Psychiatry 44 (2013): 94-99. https://doi.org/10.1016/j.pnpbp.2013.02.002

Mustapić, M., et al. (2013) 'Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 44, str. 94-99. doi: 10.1016/j.pnpbp.2013.02.002

Mustapić M, Presečki P, Pivac N, Mimica N, Hof PR, Šimić G, i sur.. Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 01.07.2013. [pristupljeno 20.12.2024.];44:94-99. doi: 10.1016/j.pnpbp.2013.02.002

M. Mustapić, et al., "Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 44, str. 94-99, Srpanj 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:515384. [Citirano: 20.12.2024.]

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Podaci o radu
Naslov (engleski)Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease
AutorMaja Mustapić
AutorPaola Presečki
AutorNela Pivac
AutorNinoslav Mimica
AutorPatrick R. Hof
AutorGoran Šimić
AutorVera Folnegović-Šmalc
AutorDorotea Muck-Šeler
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The noradrenergic system is involved in the etiology and progression of Alzheimer's disease (AD) but its role is still unclear. Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Plasma DBH (pDBH) activity shows wide inheritable interindividual variability that is under genetic control. The aim of this study was to determine pDBH activity, DBH (C-970T; rs1611115) and DBH (C1603T; rs6271) gene polymorphisms in 207 patients with AD and in 90 healthy age-matched controls. Plasma DBH activity was lower, particularly in the early stage of AD, compared to values in middle and late stages of the disease, as well as to control values. Two-way ANOVA revealed significant effect of both diagnosis and DBH (C-970T) or DBH (C1603T) genotypes on pDBH activity, but without significant diagnosis×genotype interaction. No association was found between AD and DBH C-970T (OR=1.08, 95% CI 1.13-4.37; p=0.779) and C1603T (OR=0.89; 95% CI 0.36-2.20; p=0.814) genotypes controlled for age, gender, and ApoE4 allele. The decrease in pDBH activity, found in early phase of AD suggests that alterations in DBH activity represent a compensatory mechanism for the loss of noradrenergic neurons, and that treatment with selective NA reuptake inhibitors may be indicated in early stages of AD to compensate for loss of noradrenergic activity in the locus coeruleus.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neuro-Psychopharmacology and Biological Psychiatry
Brojčani podacivol. 44, str. 94-99
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2013.02.002
URN:NBNurn:nbn:hr:105:515384
Datum objave publikacije2013-07-01
URL dokumentahttps://doi.org/10.1016/j.pnpbp.2013.02.002
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:02:30