prikaz prve stranice dokumenta Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells
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Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells
Leukemia Research, 37 (2013), 6; 705-712. https://doi.org/10.1016/j.leukres.2013.03.002
Topić, Iva; Ikić, Marina; Ivčević, Sanja; Kovačić, Nataša; Marušić, Ana; Kušec, Rajko; Grčević, Danka

Citirajte ovaj rad

Topić, I., Ikić, M., Ivčević, S., Kovačić, N., Marušić, A., Kušec, R. i Grčević, D. (2013). Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells. Leukemia Research, 37. (6), 705-712. doi: 10.1016/j.leukres.2013.03.002

Topić, Iva, et al. "Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells." Leukemia Research, vol. 37, br. 6, 2013, str. 705-712. https://doi.org/10.1016/j.leukres.2013.03.002

Topić, Iva, Marina Ikić, Sanja Ivčević, Nataša Kovačić, Ana Marušić, Rajko Kušec i Danka Grčević. "Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells." Leukemia Research 37, br. 6 (2013): 705-712. https://doi.org/10.1016/j.leukres.2013.03.002

Topić, I., et al. (2013) 'Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells', Leukemia Research, 37(6), str. 705-712. doi: 10.1016/j.leukres.2013.03.002

Topić I, Ikić M, Ivčević S, Kovačić N, Marušić A, Kušec R, i sur.. Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells. Leukemia Research [Internet]. 06.2013. [pristupljeno 15.04.2024.];37(6):705-712. doi: 10.1016/j.leukres.2013.03.002

I. Topić, et al., "Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells", Leukemia Research, vol. 37, br. 6, str. 705-712, Lipanj 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:799592. [Citirano: 15.04.2024.]

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Podaci o radu
Naslov (engleski)Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells
AutorIva Topić
AutorMarina Ikić
AutorSanja Ivčević
AutorNataša Kovačić
AutorAna Marušić
AutorRajko Kušec
AutorDanka Grčević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaLeukemia Research
Brojčani podacivol. 37, br. 6, str. 705-712
p-ISSN0145-2126
DOIhttps://doi.org/10.1016/j.leukres.2013.03.002
URN:NBNurn:nbn:hr:105:799592
Datum objave publikacije2013-06
URL dokumentahttps://doi.org/10.1016/j.leukres.2013.03.002
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 20:02:50