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TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions
Experimental and Molecular Pathology, 83 (2007), 1; 54-58. https://doi.org/10.1016/j.yexmp.2006.11.004
Sirotković-Skerlev, Maja; Čačev, Tamara; Križanac, Šimun; Kulić, Ana; Pavelić, Krešimir; Kapitanović, Sanja

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Sirotković Skerlev, M., Čačev, T., Križanac, Š., Kulić, A., Pavelić, K. i Kapitanović, S. (2007). TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions. Experimental and Molecular Pathology, 83. (1), 54-58. doi: 10.1016/j.yexmp.2006.11.004

Sirotković Skerlev, Maja, et al. "TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions." Experimental and Molecular Pathology, vol. 83, br. 1, 2007, str. 54-58. https://doi.org/10.1016/j.yexmp.2006.11.004

Sirotković Skerlev, Maja, Tamara Čačev, Šimun Križanac, Ana Kulić, Krešimir Pavelić i Sanja Kapitanović. "TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions." Experimental and Molecular Pathology 83, br. 1 (2007): 54-58. https://doi.org/10.1016/j.yexmp.2006.11.004

Sirotković Skerlev, M., et al. (2007) 'TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions', Experimental and Molecular Pathology, 83(1), str. 54-58. doi: 10.1016/j.yexmp.2006.11.004

Sirotković Skerlev M, Čačev T, Križanac Š, Kulić A, Pavelić K, Kapitanović S. TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions. Experimental and Molecular Pathology [Internet]. 08.2007. [pristupljeno 01.12.2024.];83(1):54-58. doi: 10.1016/j.yexmp.2006.11.004

M. Sirotković Skerlev, T. Čačev, Š. Križanac, A. Kulić, K. Pavelić i S. Kapitanović, "TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions", Experimental and Molecular Pathology, vol. 83, br. 1, str. 54-58, Kolovoz 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:469921. [Citirano: 01.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:469921
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Naslov (engleski)TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions
AutorMaja Sirotković-Skerlev
AutorTamara Čačev
AutorŠimun Križanac
AutorAna Kulić
AutorKrešimir Pavelić
AutorSanja Kapitanović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Polymorphisms in genes involved in the complex mechanisms of carcinogenesis may affect the susceptibility to cancer. The multifunctional cytokine tumor necrosis factor alpha (TNF alpha) has an important role in the pathogenesis of inflammatory, autoimmune and malignant diseases. It has a large spectrum of activities, including both antitumorigenic and protumorigenic. In recent years, several TNF alpha promoter polymorphisms have been identified and related to the expression level of cytokine and to the susceptibility to solid tumors. The aim of our study was to investigate the frequency of three TNF alpha promoter polymorphisms (-1031, -308 and -238) in benign (fibrocystic changes) and malignant (invasive carcinoma) breast lesions. Using "real-time" PCR SNP analysis these polymorphisms were determined in 76 patients with benign and 158 patients with malignant breast lesions. The high expression genotypes at any of the three SNP polymorphisms were more frequent in invasive breast carcinoma (in 81 of 158 examined, 51.3%) than in fibrocystic changes (in 33 of 76 examined, 43.4%). The combined frequency of high production genotypes (-1031 T/C and C/C, -308 G/A and A/A and -238 G/A and A/A) was higher in patients with invasive breast carcinoma than in those with fibrocystic changes. However, these results were not statistically significant. Further studies on a larger group of patients are needed to evaluate the significance of potential differences in TNF alpha genotypes in different breast lesions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaExperimental and Molecular Pathology
Brojčani podacivol. 83, br. 1, str. 54-58
p-ISSN0014-4800
DOIhttps://doi.org/10.1016/j.yexmp.2006.11.004
URN:NBNurn:nbn:hr:105:469921
Datum objave publikacije2007-08
URL dokumentahttps://doi.org/10.1016/j.yexmp.2006.11.004
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:06:59