Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report

Znanstveni rad - Prikaz slučaja

• Autor: Milan Radoš
• Autor: Marijan Klarica
• Autor: Branka Mučić-Pucić
• Autor: Ines Nikić
• Autor: Marina Raguž
• Autor: Valentina Galkowski
• Autor: Dora Mandić
• Autor: Darko Orešković
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti

Sažetak (engleski)

The aim of this study was to perform for the first time the intracranial volumetric analysis of cerebrospinal fluid (CSF) and brain parenchyma in the supratentorial and infratentorial space in a 30-year-old female patient with hydranencephaly and macrocephaly. A head scan performed using a 3T magnetic resonance was followed by manual segmentation of the brain parenchyma and CSF on T2 coronal brain sections. The volume of CSF and brain parenchyma was measured separately for the supratentorial and infratentorial space. The total volume of the intracranial space was 3645.5 cm(3). In the supratentorial space, the volume of CSF was 3375.2 cm(3) and the volume of brain parenchyma was 80.3 cm(3). In the infratentorial space, the volume of CSF was 101.3 cm(3) and the volume of the brain parenchyma was 88.7 cm(3). In the supratentorial space, there was severe malacia of almost all brain parenchyma with no visible remnants of the choroid plexuses. Infratentorial structures of the brainstem and cerebellum were hypoplastic but completely developed. Since our patient had no choroid plexuses in the supratentorial space and no obstruction between dural sinuses and CSF, development of hydrocephalus and macrocephaly cannot be explained by the classic hypothesis of CSF physiology with secretion, unidirectional circulation, and absorption as its basic postulates. However, the origin and turnover of the enormous amount of intracranial CSF volume, at least 10-fold larger than normal, and the mechanisms of macroencephaly development could be elucidated by the new hypothesis of CSF physiology recently published by our research team.

• Ključne riječi (engleski): Adult; Brain / pathology; Brain / physiopathology; Female; Humans; Hydranencephaly / cerebrospinal fluid; Hydranencephaly / complications; Magnetic Resonance Imaging; Megalencephaly / cerebrospinal fluid; Megalencephaly / complications; Persistent Vegetative State / cerebrospinal fluid; Persistent Vegetative State / etiology
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Prikaz slučaja
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Croatian Medical Journal
• Brojčani podaci: vol. 55, br. 4, str. 388-393
• p-ISSN: 0353-9504
• DOI: https://doi.org/10.3325/cmj.2014.55.388
• URN:NBN: urn:nbn:hr:105:826519
• Datum objave publikacije: 2014-08-28
• URL dokumenta: https://doi.org/10.3325/cmj.2014.55.388
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-27 20:10:31