prikaz prve stranice dokumenta Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
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Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
Acta Neurobiologiae Experimentalis, 74 (2014), 3; 257-265. urn:nbn:hr:105:900226
Bačić Baronica, Koraljka; Mlinac, Kristina; Petlevski, Roberta; Ozretić, David; Vladić, Anton; Kalanj-Bognar, Svjetlana; Žuntar, Irena

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Bačić Baronica, K., Mlinac, K., Petlevski, R., Ozretić, D., Vladić, A., Kalanj Bognar, S. i Žuntar, I. (2014). Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway. Acta Neurobiologiae Experimentalis, 74. (3), 257-265. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:900226

Bačić Baronica, Koraljka, et al. "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway." Acta Neurobiologiae Experimentalis, vol. 74, br. 3, 2014, str. 257-265. https://urn.nsk.hr/urn:nbn:hr:105:900226

Bačić Baronica, Koraljka, Kristina Mlinac, Roberta Petlevski, David Ozretić, Anton Vladić, Svjetlana Kalanj Bognar i Irena Žuntar. "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway." Acta Neurobiologiae Experimentalis 74, br. 3 (2014): 257-265. https://urn.nsk.hr/urn:nbn:hr:105:900226

Bačić Baronica, K., et al. (2014) 'Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway', Acta Neurobiologiae Experimentalis, 74(3), str. 257-265. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:900226 (Datum pristupa: 02.05.2024.)

Bačić Baronica K, Mlinac K, Petlevski R, Ozretić D, Vladić A, Kalanj Bognar S, i sur.. Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway. Acta Neurobiologiae Experimentalis [Internet]. 2014. [pristupljeno 02.05.2024.];74(3):257-265. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:900226

K. Bačić Baronica, et al., "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway", Acta Neurobiologiae Experimentalis, vol. 74, br. 3, str. 257-265, 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:900226. [Citirano: 02.05.2024.]

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Naslov (engleski)Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
AutorKoraljka Bačić Baronica
AutorKristina Mlinac
AutorRoberta Petlevski
AutorDavid Ozretić
AutorAnton Vladić
AutorSvjetlana Kalanj-Bognar
AutorIrena Žuntar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The impact of glutathione S-transferases (GSTs) detoxification pathway on complex pathogenesis and heterogeneity of clinical findings in multiple sclerosis (MS), particularly the exact correlation between indicators of clinical severity and different GST genotypes, has not yet been fully elucidated. The aim of the study was to assess the relationship between disability level in multiple sclerosis (estimated by Kurtzke Expanded Disability Status Scale), disease progression (estimated by Multiple Sclerosis Severity Score), the level of brain atrophy and lesion load (determined by MRI) and detoxification status (analyzing glutathione S-transferase P1, GSTP1, genotype profile), in a group of 58 MS patients and 68 age/gendermatched controls. The results present the first evidence on significantly higher frequency of GSTP1 C341T polymorphism (C-T transition) in healthy subjects compared to MS patients, suggesting it may act as a moderating factor in developing MS clinical phenotype. Gender-dependent distribution of the C341T polymorphism was found in both MS patients and controls, with higher frequency of C-T transition in females. In addition, preliminary data showed higher proportion of male MS patients with higher median MSSS scores, as well as lower brain atrophy level and lesion load in MS patients carrying the C341T mutation. Observed gender difference in distribution of the C341T polymorphism in MS patients, as well as in disease progression, suggests that GSTP1 detoxification pathway occurs in a gender-dependent manner and could therefore add to clinical severity in male MS patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Neurobiologiae Experimentalis
Brojčani podacivol. 74, br. 3, str. 257-265
p-ISSN1689-0035
URN:NBNurn:nbn:hr:105:900226
Datum objave publikacije2014
URL dokumentahttp://www.ane.pl/linkout.php?pii=7425
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-27 20:14:26