prikaz prve stranice dokumenta Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial
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Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial
Trials, 15 (2014), 1; 414. https://doi.org/10.1186/1745-6215-15-414
Gašparović, Hrvoje; Kopjar, Tomislav; Radoš, Milan; Antičević, Alan; Radoš, Marko; Malojčić, Branko; Ivančan, Višnja; Fabijanić, Tea; Čikeš, Maja; Miličić, Davor; Gašparović, Vladimir; Biočina, Bojan

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Gašparović, H., Kopjar, T., Radoš, M., Antičević, A., Radoš, M., Malojčić, B. ... Biočina, B. (2014). Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial. Trials, 15. (1), 414. doi: 10.1186/1745-6215-15-414

Gašparović, Hrvoje, et al. "Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial." Trials, vol. 15, br. 1, 2014, str. 414. https://doi.org/10.1186/1745-6215-15-414

Gašparović, Hrvoje, Tomislav Kopjar, Milan Radoš, Alan Antičević, Marko Radoš, Branko Malojčić, Višnja Ivančan, et al. "Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial." Trials 15, br. 1 (2014): 414. https://doi.org/10.1186/1745-6215-15-414

Gašparović, H., et al. (2014) 'Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial', Trials, 15(1), str. 414. doi: 10.1186/1745-6215-15-414

Gašparović H, Kopjar T, Radoš M, Antičević A, Radoš M, Malojčić B, i sur.. Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial. Trials [Internet]. 27.10.2014. [pristupljeno 27.04.2024.];15(1):414. doi: 10.1186/1745-6215-15-414

H. Gašparović, et al., "Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial", Trials, vol. 15, br. 1, str. 414, Listopad 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:645701. [Citirano: 27.04.2024.]

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Naslov (engleski)Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial
AutorHrvoje Gašparović
AutorTomislav Kopjar
AutorMilan Radoš
AutorAlan Antičević
AutorMarko Radoš
AutorBranko Malojčić
AutorVišnja Ivančan
AutorTea Fabijanić
AutorMaja Čikeš
AutorDavor Miličić
AutorVladimir Gašparović
AutorBojan Biočina
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Neurological complications after cardiac surgery have a profound impact on postoperative survival and quality of life. The increasing importance of strategies designed to improve neurological outcomes mirrors the growing risk burden of the contemporary cardiac surgical population. Remote ischemic preconditioning (RIPC) reduces adverse sequelae of ischemia in vulnerable organs by subjecting tissues with high ischemic tolerance to brief periods of hypoperfusion. This trial will evaluate the neuroprotective effect of RIPC in the cardiac surgical arena, by employing magnetic resonance imaging (MRI) and neurocognitive testing. ----- METHODS: Patients scheduled for elective coronary artery bypass grafting with the use of cardiopulmonary bypass will be screened for the study. Eligible patients will be randomized to undergo either a validated RIPC protocol or a sham procedure. The RIPC will be induced by inflation of a blood pressure cuff to 200 mmHg for 5 minutes, followed by a 5-minute reperfusion period. Three sequences of interchanging cuff inflations and deflations will be employed. Neurocognitive testing and MRI imaging will be performed preoperatively and on postoperative day 7. Paired pre- and postoperative neurocognitive and neuroimaging data will then be compared. The primary composite outcome measure will consist of new ischemic lesions on brain MRI, postprocedural impairment in brain connectivity on resting-state functional MRI (rs-fMRI), and significant new declines in neurocognitive performance. The secondary endpoint measures will be the individual components of the primary endpoint measures, expressed as continuous variables, troponin T release on postoperative day 1 and the incidence of major adverse cardiovascular events at 3 months postoperatively. Major adverse cardiovascular events, including accumulating cardiovascular mortality, stroke, nonfatal myocardial infarction, and rehospitalization for ischemia, will form a composite endpoint measure. ----- DISCUSSION: This trial will aim to assess whether RIPC in patients subjected to surgical myocardial revascularization employing cardiopulmonary bypass initiates a neuroprotective response. Should the results of this trial indicate that RIPC is effective in reducing the incidence of adverse neurological events in patients undergoing coronary artery bypass grafting, it could impact on the current standard of care.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaTrials
Brojčani podacivol. 15, br. 1, str. 414
p-ISSN1745-6215
DOIhttps://doi.org/10.1186/1745-6215-15-414
URN:NBNurn:nbn:hr:105:645701
Datum objave publikacije2014-10-27
URL dokumentahttps://doi.org/10.1186/1745-6215-15-414
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-27 20:17:39