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The rational use of animal models in the evaluation of novel bone regenerative therapies
Bone, 70 (2015); 73-86. https://doi.org/10.1016/j.bone.2014.07.010
Perić, Mihaela; Dumić-Čule, Ivo; Grčević, Danka; Matijašić, Mario; Verbanac, Donatella; Paul, Ruth; Grgurević, Lovorka; Trkulja, Vladimir; Bagi, Čedo M.; Vukičević, Slobodan

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Perić, M., Dumić Čule, I., Grčević, D., Matijašić, M., Verbanac, D., Paul, R. ... Vukičević, S. (2015). The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone, 70., 73-86. doi: 10.1016/j.bone.2014.07.010

Perić, Mihaela, et al. "The rational use of animal models in the evaluation of novel bone regenerative therapies." Bone, vol. 70, 2015, str. 73-86. https://doi.org/10.1016/j.bone.2014.07.010

Perić, Mihaela, Ivo Dumić Čule, Danka Grčević, Mario Matijašić, Donatella Verbanac, Ruth Paul, Lovorka Grgurević, Vladimir Trkulja, Čedo M. Bagi i Slobodan Vukičević. "The rational use of animal models in the evaluation of novel bone regenerative therapies." Bone 70 (2015): 73-86. https://doi.org/10.1016/j.bone.2014.07.010

Perić, M., et al. (2015) 'The rational use of animal models in the evaluation of novel bone regenerative therapies', Bone, 70, str. 73-86. doi: 10.1016/j.bone.2014.07.010

Perić M, Dumić Čule I, Grčević D, Matijašić M, Verbanac D, Paul R, i sur.. The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone [Internet]. 01.2015. [pristupljeno 24.04.2024.];70:73-86. doi: 10.1016/j.bone.2014.07.010

M. Perić, et al., "The rational use of animal models in the evaluation of novel bone regenerative therapies", Bone, vol. 70, str. 73-86, Siječanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:459882. [Citirano: 24.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:459882
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Podaci o radu
Naslov (engleski)The rational use of animal models in the evaluation of novel bone regenerative therapies
AutorMihaela Perić
AutorIvo Dumić-Čule
AutorDanka Grčević
AutorMario Matijašić
AutorDonatella Verbanac
AutorRuth Paul
AutorLovorka Grgurević
AutorVladimir Trkulja
AutorČedo M. Bagi
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Bone has a high potential for endogenous self-repair. However, due to population aging, human diseases with impaired bone regeneration are on the rise. Current strategies to facilitate bone healing include various biomolecules, cellular therapies, biomaterials and different combinations of these. Animal models for testing novel regenerative therapies remain the gold standard in pre-clinical phases of drug discovery and development. Despite improvements in animal experimentation, excessive poorly designed animal studies with inappropriate endpoints and inaccurate conclusions are being conducted. In this review, we discuss animal models, procedures, methods and technologies used in bone repair studies with the aim to assist investigators in planning and performing scientifically sound experiments that respect the wellbeing of animals. In the process of designing an animal study for bone repair investigators should consider: skeletal characteristics of the selected animal species; a suitable animal model that mimics the intended clinical indication; an appropriate assessment plan with validated methods, markers, timing, endpoints and scoring systems; relevant dosing and statistically pre-justified sample sizes and evaluation methods; synchronization of the study with regulatory requirements and additional evaluations specific to cell-based approaches. This article is part of a Special Issue entitled "Stem Cells and Bone".
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaBone
Brojčani podacivol. 70, str. 73-86
p-ISSN8756-3282
DOIhttps://doi.org/10.1016/j.bone.2014.07.010
URN:NBNurn:nbn:hr:105:459882
Datum objave publikacije2015-01
URL dokumentahttps://doi.org/10.1016/j.bone.2014.07.010
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:03:01