prikaz prve stranice dokumenta Extraordinary neoteny of synaptic spines in the human prefrontal cortex
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Extraordinary neoteny of synaptic spines in the human prefrontal cortex
Proceedings of the National Academy of Sciences, 108 (2011), 32; 13281-13286. https://doi.org/10.1073/pnas.1105108108
Petanjek, Zdravko; Judaš, Miloš; Šimić, Goran; Rašin, Mladen Roko; Uylings, Harry B. M.; Rakic, Pasko; Kostović, Ivica

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Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P. i Kostović, I. (2011). Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proceedings of the National Academy of Sciences, 108. (32), 13281-13286. doi: 10.1073/pnas.1105108108

Petanjek, Zdravko, et al. "Extraordinary neoteny of synaptic spines in the human prefrontal cortex." Proceedings of the National Academy of Sciences, vol. 108, br. 32, 2011, str. 13281-13286. https://doi.org/10.1073/pnas.1105108108

Petanjek, Zdravko, Miloš Judaš, Goran Šimić, Mladen Roko Rašin, Harry B. M. Uylings, Pasko Rakic i Ivica Kostović. "Extraordinary neoteny of synaptic spines in the human prefrontal cortex." Proceedings of the National Academy of Sciences 108, br. 32 (2011): 13281-13286. https://doi.org/10.1073/pnas.1105108108

Petanjek, Z., et al. (2011) 'Extraordinary neoteny of synaptic spines in the human prefrontal cortex', Proceedings of the National Academy of Sciences, 108(32), str. 13281-13286. doi: 10.1073/pnas.1105108108

Petanjek Z, Judaš M, Šimić G, Rašin MR, Uylings HBM, Rakic P, i sur.. Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proceedings of the National Academy of Sciences [Internet]. 09.08.2011. [pristupljeno 08.11.2024.];108(32):13281-13286. doi: 10.1073/pnas.1105108108

Z. Petanjek, et al., "Extraordinary neoteny of synaptic spines in the human prefrontal cortex", Proceedings of the National Academy of Sciences, vol. 108, br. 32, str. 13281-13286, Kolovoz 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:102068. [Citirano: 08.11.2024.]

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Podaci o radu
Naslov (engleski)Extraordinary neoteny of synaptic spines in the human prefrontal cortex
AutorZdravko Petanjek
AutorMiloš Judaš
AutorGoran Šimić
AutorMladen Roko Rašin
AutorHarry B. M. Uylings
AutorPasko Rakic
AutorIvica Kostović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The major mechanism for generating diversity of neuronal connections beyond their genetic determination is the activity-dependent stabilization and selective elimination of the initially overproduced synapses [Changeux JP, Danchin A (1976) Nature 264:705-712]. The largest number of supranumerary synapses has been recorded in the cerebral cortex of human and nonhuman primates. It is generally accepted that synaptic pruning in the cerebral cortex, including prefrontal areas, occurs at puberty and is completed during early adolescence [Huttenlocher PR, et al. (1979) Brain Res 163:195-205]. In the present study we analyzed synaptic spine density on the dendrites of layer IIIC cortico-cortical and layer V cortico-subcortical projecting pyramidal neurons in a large sample of human prefrontal cortices in subjects ranging in age from newborn to 91 y. We confirm that dendritic spine density in childhood exceeds adult values by two- to threefold and begins to decrease during puberty. However, we also obtained evidence that overproduction and developmental remodeling, including substantial elimination of synaptic spines, continues beyond adolescence and throughout the third decade of life before stabilizing at the adult level. Such an extraordinarily long phase of developmental reorganization of cortical neuronal circuitry has implications for understanding the effect of environmental impact on the development of human cognitive and emotional capacities as well as the late onset of human-specific neuropsychiatric disorders.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaProceedings of the National Academy of Sciences
Brojčani podacivol. 108, br. 32, str. 13281-13286
p-ISSN0027-8424
DOIhttps://doi.org/10.1073/pnas.1105108108
URN:NBNurn:nbn:hr:105:102068
Datum objave publikacije2011-08-09
URL dokumentahttps://doi.org/10.1073/pnas.1105108108
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:04:42