prikaz prve stranice dokumenta Botulinum toxin A, brain and pain
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Botulinum toxin A, brain and pain
Progress in Neurobiology, 119-20 (2014); 39-59. https://doi.org/10.1016/j.pneurobio.2014.06.001
Matak, Ivica; Lacković, Zdravko

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Matak, I. i Lacković, Z. (2014). Botulinum toxin A, brain and pain. Progress in Neurobiology, 119-20., 39-59. doi: 10.1016/j.pneurobio.2014.06.001

Matak, Ivica i Zdravko Lacković. "Botulinum toxin A, brain and pain." Progress in Neurobiology, vol. 119-20, 2014, str. 39-59. https://doi.org/10.1016/j.pneurobio.2014.06.001

Matak, Ivica i Zdravko Lacković. "Botulinum toxin A, brain and pain." Progress in Neurobiology 119-20 (2014): 39-59. https://doi.org/10.1016/j.pneurobio.2014.06.001

Matak, I. i Lacković, Z. (2014) 'Botulinum toxin A, brain and pain', Progress in Neurobiology, 119-20, str. 39-59. doi: 10.1016/j.pneurobio.2014.06.001

Matak I, Lacković Z. Botulinum toxin A, brain and pain. Progress in Neurobiology [Internet]. 08.2014. [pristupljeno 08.11.2024.];119-20:39-59. doi: 10.1016/j.pneurobio.2014.06.001

I. Matak i Z. Lacković, "Botulinum toxin A, brain and pain", Progress in Neurobiology, vol. 119-20, str. 39-59, Kolovoz 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:932616. [Citirano: 08.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:932616
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Podaci o radu
Naslov (engleski)Botulinum toxin A, brain and pain
AutorIvica Matak
AutorZdravko Lacković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins known and a potential biological threat. At the same time, it is among the most widely used therapeutic proteins used yearly by millions of people, especially for cosmetic purposes. Currently, its clinical use in certain types of pain is increasing, and its long-term duration of effects represents a special clinical value. Efficacy of BoNT/A in different types of pain has been found in numerous clinical trials and case reports, as well as in animal pain models. However, sites and mechanisms of BoNT/A actions involved in nociception are a matter of controversy. In analogy with well known neuroparalytic effects in peripheral cholinergic synapses, presently dominant opinion is that BoNT/A exerts pain reduction by inhibiting peripheral neurotransmitter/inflammatory mediator release from sensory nerves. On the other hand, growing number of behavioral and immunohistochemical studies demonstrated the requirement of axonal transport for BoNT/A's antinociceptive action. In addition, toxin's enzymatic activity in central sensory regions was clearly identified after its peripheral application. Apart from general pharmacology, this review summarizes the clinical and experimental evidence for BoNT/A antinociceptive activity and compares the data in favor of peripheral vs. central site and mechanism of action. Based on literature review and published results from our laboratory we propose that the hypothesis of peripheral site of BoNT/A action is not sufficient to explain the experimental data collected up to now.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neurobiology
Brojčani podacivol. 119-20, str. 39-59
p-ISSN0301-0082
DOIhttps://doi.org/10.1016/j.pneurobio.2014.06.001
URN:NBNurn:nbn:hr:105:932616
Datum objave publikacije2014-08
URL dokumentahttp://doi.org/10.1016/j.pneurobio.2014.06.001
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:08:21