prikaz prve stranice dokumenta Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse
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Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse
Neuroscience Letters, 597 (2015); 176-82. https://doi.org/10.1016/j.neulet.2015.04.042
Gorup, Dunja; Bohaček, Ivan; Miličević, Tena; Pochet, Roland; Mitrečić, Dinko; Križ, Jasna; Gajović, Srećko

Citirajte ovaj rad

Gorup, D., Bohaček, I., Miličević, T., Pochet, R., Mitrečić, D., Križ, J. i Gajović, S. (2015). Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse. Neuroscience Letters, 597., 176-82. doi: 10.1016/j.neulet.2015.04.042

Gorup, Dunja, et al. "Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse." Neuroscience Letters, vol. 597, 2015, str. 176-82. https://doi.org/10.1016/j.neulet.2015.04.042

Gorup, Dunja, Ivan Bohaček, Tena Miličević, Roland Pochet, Dinko Mitrečić, Jasna Križ i Srećko Gajović. "Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse." Neuroscience Letters 597 (2015): 176-82. https://doi.org/10.1016/j.neulet.2015.04.042

Gorup, D., et al. (2015) 'Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse', Neuroscience Letters, 597, str. 176-82. doi: 10.1016/j.neulet.2015.04.042

Gorup D, Bohaček I, Miličević T, Pochet R, Mitrečić D, Križ J, i sur.. Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse. Neuroscience Letters [Internet]. 15.06.2015. [pristupljeno 18.10.2024.];597:176-82. doi: 10.1016/j.neulet.2015.04.042

D. Gorup, et al., "Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse", Neuroscience Letters, vol. 597, str. 176-82, Lipanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:897203. [Citirano: 18.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:897203
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Podaci o radu
Naslov (engleski)Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse
AutorDunja Gorup
AutorIvan Bohaček
AutorTena Miličević
AutorRoland Pochet
AutorDinko Mitrečić
AutorJasna Križ
AutorSrećko Gajović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
GAP43 is a protein involved in neurite outgrowth during development and axon regeneration reflecting its presynaptic localization in developing neurons. Recently, it has been demonstrated that GAP43 is a ligand of CASP3 involved in receptor endocytosis and is also localized post-synaptically. In this study, by using a transgenic mouse strain carrying a bioluminescent reporter for GAP43 combined with an in vivo bioluminescence assay for CASP3, we demonstrated that one day after brain ischemic lesion and, even more pronounced, four days after stroke, expression of both CASP3 and Gap43 in neurons increased more than 40 times. The in vivo approach of CASP3 and GAP43 colocalization imaging was further validated and quantified by immunofluorescence. Importantly, in 82% of GAP43 positive cells, colocalization with CASP3 was present. These findings suggested that one and four days after stroke CASP3 expression, not necessarily associated with neuronal death, increased and suggested that CASP3 and GAP43 might be part of a common molecular pathway involved in early response to ischemic events occurring after onset of stroke.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeuroscience Letters
Brojčani podacivol. 597, str. 176-82
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2015.04.042
URN:NBNurn:nbn:hr:105:897203
Datum objave publikacije2015-06-15
URL dokumentahttps://doi.org/10.1016/j.neulet.2015.04.042
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:10:50