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Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction
Journal of Molecular Psychiatry, 3 (2015), 1; 6. https://doi.org/10.1186/s40303-015-0012-6
Grünblatt, Edna; Bartl, Jasmin; Iuhos, Diana-Iulia; Knezović, Ana; Trkulja, Vladimir; Riederer, Peter; Walitza, Susanne; Šalković-Petrišić, Melita

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Grünblatt, E., Bartl, J., Iuhos, D. I., Knezović, A., Trkulja, V., Riederer, P. ... Šalković Petrišić, M. (2015). Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction. Journal of Molecular Psychiatry, 3. (1), 6. doi: 10.1186/s40303-015-0012-6

Grünblatt, Edna, et al. "Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction." Journal of Molecular Psychiatry, vol. 3, br. 1, 2015, str. 6. https://doi.org/10.1186/s40303-015-0012-6

Grünblatt, Edna, Jasmin Bartl, Diana Iulia Iuhos, Ana Knezović, Vladimir Trkulja, Peter Riederer, Susanne Walitza i Melita Šalković Petrišić. "Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction." Journal of Molecular Psychiatry 3, br. 1 (2015): 6. https://doi.org/10.1186/s40303-015-0012-6

Grünblatt, E., et al. (2015) 'Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction', Journal of Molecular Psychiatry, 3(1), str. 6. doi: 10.1186/s40303-015-0012-6

Grünblatt E, Bartl J, Iuhos DI, Knezović A, Trkulja V, Riederer P, i sur.. Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction. Journal of Molecular Psychiatry [Internet]. 04.06.2015. [pristupljeno 13.03.2025.];3(1):6. doi: 10.1186/s40303-015-0012-6

E. Grünblatt, et al., "Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction", Journal of Molecular Psychiatry, vol. 3, br. 1, str. 6, Lipanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:621118. [Citirano: 13.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:621118
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Naslov (engleski)Characterization of cognitive deficits in spontaneously hypertensive rats, accompanied by brain insulin receptor dysfunction
AutorEdna Grünblatt
AutorJasmin Bartl
AutorDiana-Iulia Iuhos
AutorAna Knezović
AutorVladimir Trkulja
AutorPeter Riederer
AutorSusanne Walitza
AutorMelita Šalković-Petrišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
BACKGROUND The spontaneously hypertensive rat (SHR) has been used to model changes in the central nervous system associated with cognitive-related disorders. Recent human and animal studies indicate a possible relationship between cognitive deficits, insulin resistance and hypertension. We aimed to investigate whether cognitively impaired SHRs develop central and/or peripheral insulin resistance and how their cognitive performance is influenced by the animal's sex and age as well as strains used for comparison (Wistar and Wistar-Kyoto/WKY). ----- METHODS Three and seven-month-old SHR, Wistar, and WKY rats were studied for their cognitive performance using Morris Water Maze (MWM) and Passive Avoidance tests (PAT). Plasma glucose and insulin were obtained after oral glucose tolerance tests. Cerebral cortex, hippocampus, and striatum status of insulin-receptor (IR) β-subunit and glycogen synthase kinase-3β (GSK3β) and their phosphorylated forms were obtained via ELISA. ----- RESULTS SHRs performed poorly in MWM and PAT in comparison to both control strains but more pronouncedly compared to WKY. Females performed poorer than males and 7-month-old SHRs had poorer MWM performance than 3-month-old ones. Although plasma glucose levels remained unchanged, plasma insulin levels were significantly increased in the glucose tolerance test in 7-month-old SHRs. SHRs demonstrated reduced expression and increased activity of IRβ-subunit in cerebral cortex, hippocampus, and striatum with different regional changes in phospho/total GSK3β ratio, as compared to WKYs. ----- CONCLUSION Results indicate that cognitive deficits in SHRs are accompanied by both central and peripheral insulin dysfunction, thus allowing for the speculation that SHRs might additionally be considered as a model of insulin resistance-induced type of dementia.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Molecular Psychiatry
Brojčani podacivol. 3, br. 1, str. 6
p-ISSN2049-9256
DOIhttps://doi.org/10.1186/s40303-015-0012-6
URN:NBNurn:nbn:hr:105:621118
Datum objave publikacije2015-06-04
URL dokumentahttps://doi.org/10.1186/s40303-015-0012-6
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:11:52