prikaz prve stranice dokumenta Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa
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Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa
PLoS ONE, 10 (2015), 3; e0120981. https://doi.org/10.1371/journal.pone.0120981
Hampson, Lisa V.; Whitehead, John; Eleftheriou, Despina; Tudur-Smith, Catrin; Jones, Rachel; Jayne, David; Hickey, Helen; Beresford, Michael W.; Bracaglia, Claudia; Caldas, Afonso; Cimaz, Rolando; Dehoorne, Joke; Dolezalova, Pavla; Friswell, Mark; Jelušić, Marija; Marks, Stephen D.; Martin, Neil; McMahon, Anne-Marie; Peitz, Joachim; van Royen-Kerkhof, Annet; Soylemezoglu, Oguz; Brogan, Paul A. Više autora...

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Hampson, L. V., Whitehead, J., Eleftheriou, D., Tudur Smith, C., Jones, R., Jayne, D. ... Brogan, P. A. (2015). Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa. PLoS ONE, 10. (3). doi: 10.1371/journal.pone.0120981

Hampson, Lisa V., et al. "Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa." PLoS ONE, vol. 10, br. 3, 2015. https://doi.org/10.1371/journal.pone.0120981

Hampson, Lisa V., John Whitehead, Despina Eleftheriou, Catrin Tudur Smith, Rachel Jones, David Jayne, Helen Hickey, et al. "Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa." PLoS ONE 10, br. 3 (2015). https://doi.org/10.1371/journal.pone.0120981

Hampson, L. V., et al. (2015) 'Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa', PLoS ONE, 10(3). doi: 10.1371/journal.pone.0120981

Hampson LV, Whitehead J, Eleftheriou D, Tudur Smith C, Jones R, Jayne D, i sur.. Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa. PLoS ONE [Internet]. 30.03.2015. [pristupljeno 12.04.2024.];10(3). doi: 10.1371/journal.pone.0120981

L. V. Hampson, et al., "Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa", PLoS ONE, vol. 10, br. 3, Ožujak 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:148094. [Citirano: 12.04.2024.]

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Naslov (engleski)Elicitation of expert prior opinion: application to the MYPAN trial in childhood polyarteritis nodosa
AutorLisa V. Hampson
AutorJohn Whitehead
AutorDespina Eleftheriou
AutorCatrin Tudur-Smith
AutorRachel Jones
AutorDavid Jayne
AutorHelen Hickey
AutorMichael W. Beresford
AutorClaudia Bracaglia
AutorAfonso Caldas
AutorRolando Cimaz
AutorJoke Dehoorne
AutorPavla Dolezalova
AutorMark Friswell
AutorMarija Jelušić
AutorStephen D. Marks
AutorNeil Martin
AutorAnne-Marie McMahon
AutorJoachim Peitz
AutorAnnet van Royen-Kerkhof
AutorOguz Soylemezoglu
AutorPaul A. Brogan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES: Definitive sample sizes for clinical trials in rare diseases are usually infeasible. Bayesian methodology can be used to maximise what is learnt from clinical trials in these circumstances. We elicited expert prior opinion for a future Bayesian randomised controlled trial for a rare inflammatory paediatric disease, polyarteritis nodosa (MYPAN, Mycophenolate mofetil for polyarteritis nodosa). ----- METHODS: A Bayesian prior elicitation meeting was convened. Opinion was sought on the probability that a patient in the MYPAN trial treated with cyclophosphamide would achieve disease remission within 6-months, and on the relative efficacies of mycophenolate mofetil and cyclophosphamide. Expert opinion was combined with previously unseen data from a recently completed randomised controlled trial in ANCA associated vasculitis. ----- RESULTS: A pan-European group of fifteen experts participated in the elicitation meeting. Consensus expert prior opinion was that the most likely rates of disease remission within 6 months on cyclophosphamide or mycophenolate mofetil were 74% and 71%, respectively. This prior opinion will now be taken forward and will be modified to formulate a Bayesian posterior opinion once the MYPAN trial data from 40 patients randomised 1:1 to either CYC or MMF become available. ----- CONCLUSIONS: We suggest that the methodological template we propose could be applied to trial design for other rare diseases.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 10, br. 3, e0120981
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0120981
URN:NBNurn:nbn:hr:105:148094
Datum objave publikacije2015-03-30
URL dokumentahttps://doi.org/10.1371/journal.pone.0120981
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:11:41