prikaz prve stranice dokumenta Treatment of prolactinomas in low-income countries
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Treatment of prolactinomas in low-income countries
International Journal of Endocrinology, 2015 (2015); 697065. https://doi.org/10.1155/2015/697065
Kruljac, Ivan; Kirigin, Lora Stanka; Strinović, Mateja; Marinković, Jelena; Pećina, Hrvoje Ivan; Čerina, Vatroslav; Stipić, Darko; Vrkljan, Milan

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Kruljac, I., Kirigin, L. S., Strinović, M., Marinković, J., Pećina, H. I., Čerina, V. ... Vrkljan, M. (2015). Treatment of prolactinomas in low-income countries. International Journal of Endocrinology, 2015., 697065. doi: 10.1155/2015/697065

Kruljac, Ivan, et al. "Treatment of prolactinomas in low-income countries." International Journal of Endocrinology, vol. 2015, 2015, str. 697065. https://doi.org/10.1155/2015/697065

Kruljac, Ivan, Lora Stanka Kirigin, Mateja Strinović, Jelena Marinković, Hrvoje Ivan Pećina, Vatroslav Čerina, Darko Stipić i Milan Vrkljan. "Treatment of prolactinomas in low-income countries." International Journal of Endocrinology 2015 (2015): 697065. https://doi.org/10.1155/2015/697065

Kruljac, I., et al. (2015) 'Treatment of prolactinomas in low-income countries', International Journal of Endocrinology, 2015, str. 697065. doi: 10.1155/2015/697065

Kruljac I, Kirigin LS, Strinović M, Marinković J, Pećina HI, Čerina V, i sur.. Treatment of prolactinomas in low-income countries. International Journal of Endocrinology [Internet]. 2015. [pristupljeno 12.11.2024.];2015:697065. doi: 10.1155/2015/697065

I. Kruljac, et al., "Treatment of prolactinomas in low-income countries", International Journal of Endocrinology, vol. 2015, str. 697065, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:243767. [Citirano: 12.11.2024.]

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Naslov (engleski)Treatment of prolactinomas in low-income countries
AutorIvan Kruljac
AutorLora Stanka Kirigin
AutorMateja Strinović
AutorJelena Marinković
AutorHrvoje Ivan Pećina
AutorVatroslav Čerina
AutorDarko Stipić
AutorMilan Vrkljan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Purpose. In low-income countries, prolactinomas are difficult to manage with dopamine agonists (DA). We compared the effectiveness of DA in microprolactinomas as a first line treatment and as adjuvant therapy for residual macroprolactinomas treated surgically. ----- Methods. Our retrospective study analyzed 78 patients, 38 with microprolactinomas and 40 with macroprolactinomas. Microprolactinomas were treated with DA. Macroprolactinomas were treated with microsurgical or endoscopic adenomectomies and adjuvant DA. Surgical remission was defined as normoprolactinemia three months postoperatively, and long-term remission as normoprolactinemia at the last control. ----- Results. Surgical remission was achieved in 9 patients (23%). Postsurgical tumor mass was reduced by 50% (34-68). Residual macroprolactinoma size was greater than microprolactinoma size prior to treatment (10 mm versus 4 mm, P < 0.001). Both groups received similar doses of DA. Long-term remission occurred in 68% of microprolactinomas and 43% of macroprolactinomas (P = 0.102). Prolactin (PRL) levels at the last control were similar in both groups (23.1 versus 32.9 mcg/L, P = 0.347). ----- Conclusion. Comparable remission rates and PRL levels were reached in microprolactinomas and macroprolactinomas using similar doses of DA. Although complete tumor resection is the goal of surgery, our study suggests that even partial surgical removal has a role in treatment of prolactinomas since it may enhance the response to DA.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Endocrinology
Brojčani podacivol. 2015, str. 697065
p-ISSN1687-8337
DOIhttps://doi.org/10.1155/2015/697065
URN:NBNurn:nbn:hr:105:243767
Datum objave publikacije2015
URL dokumentahttps://doi.org/10.1155/2015/697065
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:22:00