Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: a three year prospective study

Znanstveni rad - Izvorni znanstveni rad

• Autor: Stojanka Gašparović
• Autor: Nadan Rustemović
• Autor: Milorad Opačić
• Autor: Marina Premužić
• Autor: Anđelko Korušić
• Autor: Jadranka Božikov
• Autor: Tamara Bates
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy. - - - - - METHODS: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure. - - - - - RESULTS: A statistically significant reduction in mean arterial pressure was demonstrated (P<0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P<0.001). A critical decrease in oxygen saturation (<90%) was documented in 27 patients (2.4%). - - - - - CONCLUSION: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.

• Ključne riječi (engleski): Conscious Sedation; Endoscopy, Gastrointestinal; Hypnotics and Sedatives - pharmacology; Propofol - pharmacology; Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure - drug effects; Female; Heart Rate - drug effects; Humans; Male; Middle Aged; Oxygen - blood; Prospective Studies
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: World Journal of Gastroenterology
• Brojčani podaci: vol. 12, br. 2, str. 327-330
• p-ISSN: 1007-9327
• DOI: https://doi.org/10.3748/wjg.v12.i2.327
• URN:NBN: urn:nbn:hr:105:504389
• Datum objave publikacije: 2006-01-14
• URL dokumenta: https://dx.doi.org/10.3748/wjg.v12.i2.327
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 08:24:58