prikaz prve stranice dokumenta Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis
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Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis
Clinical and Experimental Rheumatology, 31 (2013), 5; 803-812. urn:nbn:hr:105:095216
Lukić, Anita; Lukić, Ivan Krešimir; Malčić, Ivan; Batinić, Danica; Milošević, Danko; Rožmanić, Vojko; Saraga, Marijan; Šubat-Dežulović, Mirna; Metličić, Vitomir; Malenica, Branko; Jelušić, Marija

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Lukić, A., Lukić, I. K., Malčić, I., Batinić, D., Milošević, D., Rožmanić, V. ... Jelušić, M. (2013). Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis. Clinical and Experimental Rheumatology, 31. (5), 803-812. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:095216

Lukić, Anita, et al. "Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis." Clinical and Experimental Rheumatology, vol. 31, br. 5, 2013, str. 803-812. https://urn.nsk.hr/urn:nbn:hr:105:095216

Lukić, Anita, Ivan Krešimir Lukić, Ivan Malčić, Danica Batinić, Danko Milošević, Vojko Rožmanić, Marijan Saraga, et al. "Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis." Clinical and Experimental Rheumatology 31, br. 5 (2013): 803-812. https://urn.nsk.hr/urn:nbn:hr:105:095216

Lukić, A., et al. (2013) 'Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis', Clinical and Experimental Rheumatology, 31(5), str. 803-812. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:095216 (Datum pristupa: 08.11.2024.)

Lukić A, Lukić IK, Malčić I, Batinić D, Milošević D, Rožmanić V, i sur.. Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis. Clinical and Experimental Rheumatology [Internet]. 09.2013. [pristupljeno 08.11.2024.];31(5):803-812. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:095216

A. Lukić, et al., "Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis", Clinical and Experimental Rheumatology, vol. 31, br. 5, str. 803-812, Rujan 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:095216. [Citirano: 08.11.2024.]

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Naslov (engleski)Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis
AutorAnita Lukić
AutorIvan Krešimir Lukić
AutorIvan Malčić
AutorDanica Batinić
AutorDanko Milošević
AutorVojko Rožmanić
AutorMarijan Saraga
AutorMirna Šubat-Dežulović
AutorVitomir Metličić
AutorBranko Malenica
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES Childhood-onset systemic lupus erythematosus (cSLE) presents with diverse clinical features and often with non-classical symptoms that may delay diagnosis and increase risk of morbidity and mortality. This paper aims to analyse incidence, and clinical and laboratory features of cSLE in Croatia between 1991 and 2010, and to identify factors influencing time to diagnosis. ----- RESULTS Medical records at three university-based tertiary care centres were analysed retrospectively for 81 children with cSLE (68 girls). Mean age at onset was 13.4±2.8 yr (interquartile range 3), and annual incidence varied from 1-15 per million at risk. The most frequent clinical and laboratory features were musculoskeletal symptoms (80%) and increased erythrocyte sedimentation rate (96%). The most frequent immunological laboratory findings were the presence of antibodies against histones (86%), double-stranded DNA (73%), and Sm protein (64%), as well as low levels of C3 complement (69%). Haematuria was present in 58% of children, proteinuria in 56%, and biopsy-confirmed lupus nephritis in 43%. Median time from symptom onset to diagnosis was 2 months (range 0-96). Time to diagnosis was inversely associated with ECLAM score (p<0.001), but it showed no association with age, gender, clinical features or distance from the nearest paediatric centre. ----- CONCLUSIONS This is the first large-scale, in-depth study of clinical and laboratory features of cSLE in Croatia. Among all demographic, laboratory and clinical features examined, ECLAM score alone was inversely associated with time to diagnosis. This highlights the need to improve detection of children with fewer symptoms early in the course of the disease, therefore serious consequences for prognosis could be avoided.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical and Experimental Rheumatology
Brojčani podacivol. 31, br. 5, str. 803-812
p-ISSN0392-856X
URN:NBNurn:nbn:hr:105:095216
Datum objave publikacije2013-09
URL dokumentahttps://www.clinexprheumatol.org/article.asp?a=6722
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:28:55