prikaz prve stranice dokumenta Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
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Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
Biomolecules, 6 (2016), 1; 6. https://doi.org/10.3390/biom6010006
Šimić, Goran; Babić Leko, Mirjana; Wray, Selina; Harrington, Charles; Delalle, Ivana; Jovanov-Milošević, Nataša; Bažadona, Danira; Buée, Luc; de Silva, Rohan; Di Giovanni, Giuseppe; Wischik, Claude; Hof, Patrick R.

Citirajte ovaj rad

Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov Milošević, N. ... Hof, P. R. (2016). Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules, 6. (1), 6. doi: 10.3390/biom6010006

Šimić, Goran, et al. "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies." Biomolecules, vol. 6, br. 1, 2016, str. 6. https://doi.org/10.3390/biom6010006

Šimić, Goran, Mirjana Babić Leko, Selina Wray, Charles Harrington, Ivana Delalle, Nataša Jovanov Milošević, Danira Bažadona, et al. "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies." Biomolecules 6, br. 1 (2016): 6. https://doi.org/10.3390/biom6010006

Šimić, G., et al. (2016) 'Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies', Biomolecules, 6(1), str. 6. doi: 10.3390/biom6010006

Šimić G, Babić Leko M, Wray S, Harrington C, Delalle I, Jovanov Milošević N, i sur.. Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules [Internet]. 06.01.2016. [pristupljeno 01.05.2024.];6(1):6. doi: 10.3390/biom6010006

G. Šimić, et al., "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies", Biomolecules, vol. 6, br. 1, str. 6, Siječanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:938227. [Citirano: 01.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:938227
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Podaci o radu
Naslov (engleski)Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
AutorGoran Šimić
AutorMirjana Babić Leko
AutorSelina Wray
AutorCharles Harrington
AutorIvana Delalle
AutorNataša Jovanov-Milošević
AutorDanira Bažadona
AutorLuc Buée
AutorRohan de Silva
AutorGiuseppe Di Giovanni
AutorClaude Wischik
AutorPatrick R. Hof
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by the extraneuronal deposition of the amyloid β (Aβ) protein in the form of plaques and the intraneuronal aggregation of the microtubule-associated protein tau in the form of filaments. Based on the biochemically diverse range of pathological tau proteins, a number of approaches have been proposed to develop new potential therapeutics. Here we discuss some of the most promising ones: inhibition of tau phosphorylation, proteolysis and aggregation, promotion of intra- and extracellular tau clearance, and stabilization of microtubules. We also emphasize the need to achieve a full understanding of the biological roles and post-translational modifications of normal tau, as well as the molecular events responsible for selective neuronal vulnerability to tau pathology and its propagation. It is concluded that answering key questions on the relationship between Aβ and tau pathology should lead to a better understanding of the nature of secondary tauopathies, especially AD, and open new therapeutic targets and strategies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 6, br. 1, str. 6
p-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom6010006
URN:NBNurn:nbn:hr:105:938227
Datum objave publikacije2016-01-06
URL dokumentahttps://doi.org/10.3390/biom6010006
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:33:53