prikaz prve stranice dokumenta Morphological maturation of the mouse brain: an in vivo MRI and histology investigation
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Morphological maturation of the mouse brain: an in vivo MRI and histology investigation
NeuroImage, 125 (2016); 144-152. https://doi.org/10.1016/j.neuroimage.2015.10.009
Hammelrath, Luam; Škokić, Siniša; Khmelinskii, Artem; Hess, Andreas; van der Knaap, Noortje; Staring, Marius; Lelieveldt, Boudewijn P. F.; Wiedermann, Dirk; Hoehn, Mathias

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Hammelrath, L., Škokić, S., Khmelinskii, A., Hess, A., van der Knaap, N., Staring, M. ... Hoehn, M. (2016). Morphological maturation of the mouse brain: an in vivo MRI and histology investigation. NeuroImage, 125., 144-152. doi: 10.1016/j.neuroimage.2015.10.009

Hammelrath, Luam, et al. "Morphological maturation of the mouse brain: an in vivo MRI and histology investigation." NeuroImage, vol. 125, 2016, str. 144-152. https://doi.org/10.1016/j.neuroimage.2015.10.009

Hammelrath, Luam, Siniša Škokić, Artem Khmelinskii, Andreas Hess, Noortje van der Knaap, Marius Staring, Boudewijn P. F. Lelieveldt, Dirk Wiedermann i Mathias Hoehn. "Morphological maturation of the mouse brain: an in vivo MRI and histology investigation." NeuroImage 125 (2016): 144-152. https://doi.org/10.1016/j.neuroimage.2015.10.009

Hammelrath, L., et al. (2016) 'Morphological maturation of the mouse brain: an in vivo MRI and histology investigation', NeuroImage, 125, str. 144-152. doi: 10.1016/j.neuroimage.2015.10.009

Hammelrath L, Škokić S, Khmelinskii A, Hess A, van der Knaap N, Staring M, i sur.. Morphological maturation of the mouse brain: an in vivo MRI and histology investigation. NeuroImage [Internet]. 15.01.2016. [pristupljeno 21.04.2024.];125:144-152. doi: 10.1016/j.neuroimage.2015.10.009

L. Hammelrath, et al., "Morphological maturation of the mouse brain: an in vivo MRI and histology investigation", NeuroImage, vol. 125, str. 144-152, Siječanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:456676. [Citirano: 21.04.2024.]

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Podaci o radu
Naslov (engleski)Morphological maturation of the mouse brain: an in vivo MRI and histology investigation
AutorLuam Hammelrath
AutorSiniša Škokić
AutorArtem Khmelinskii
AutorAndreas Hess
AutorNoortje van der Knaap
AutorMarius Staring
AutorBoudewijn P. F. Lelieveldt
AutorDirk Wiedermann
AutorMathias Hoehn
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
With the wide access to studies of selected gene expressions in transgenic animals, mice have become the dominant species as cerebral disease models. Many of these studies are performed on animals of not more than eight weeks, declared as adult animals. Based on the earlier reports that full brain maturation requires at least three months in rats, there is a clear need to discern the corresponding minimal animal age to provide an "adult brain" in mice in order to avoid modulation of disease progression/therapy studies by ongoing developmental changes. For this purpose, we have studied anatomical brain alterations of mice during their first six months of age. Using T2-weighted and diffusion-weighted MRI, structural and volume changes of the brain were identified and compared with histological analysis of myelination. Mouse brain volume was found to be almost stable already at three weeks, but cortex thickness kept decreasing continuously with maximal changes during the first three months. Myelination is still increasing between three and six months, although most dramatic changes are over by three months. While our results emphasize that mice should be at least three months old when adult animals are needed for brain studies, preferred choice of one particular metric for future investigation goals will result in somewhat varying age windows of stabilization.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeuroImage
Brojčani podacivol. 125, str. 144-152
p-ISSN1053-8119
DOIhttps://doi.org/10.1016/j.neuroimage.2015.10.009
URN:NBNurn:nbn:hr:105:456676
Datum objave publikacije2016-01-15
URL dokumentahttps://doi.org/10.1016/j.neuroimage.2015.10.009
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:34:14