prikaz prve stranice dokumenta Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner
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Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner
Journal of Cellular and Molecular Medicine, 19 (2015), 8; 1887-1899. https://doi.org/10.1111/jcmm.12561
Riahi, Yael; Kaiser, Nurit; Cohen, Guy; Abd-Elrahman, Ihab; Blum, Galia; Shapira, Oz M.; Koler, Tomer; Simionescu, Maya; Sima, Anca V.; Žarković, Neven; Žarković, Kamelija; Orioli, Marica; Aldini, Giancarlo; Cerasi, Erol; Leibowitz, Gil; Sasson, Shlomo Više autora...

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Riahi, Y., Kaiser, N., Cohen, G., Abd Elrahman, I., Blum, G., Shapira, O. M. ... Sasson, S. (2015). Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner. Journal of Cellular and Molecular Medicine, 19. (8), 1887-1899. doi: 10.1111/jcmm.12561

Riahi, Yael, et al. "Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner." Journal of Cellular and Molecular Medicine, vol. 19, br. 8, 2015, str. 1887-1899. https://doi.org/10.1111/jcmm.12561

Riahi, Yael, Nurit Kaiser, Guy Cohen, Ihab Abd Elrahman, Galia Blum, Oz M. Shapira, Tomer Koler, et al. "Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner." Journal of Cellular and Molecular Medicine 19, br. 8 (2015): 1887-1899. https://doi.org/10.1111/jcmm.12561

Riahi, Y., et al. (2015) 'Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner', Journal of Cellular and Molecular Medicine, 19(8), str. 1887-1899. doi: 10.1111/jcmm.12561

Riahi Y, Kaiser N, Cohen G, Abd Elrahman I, Blum G, Shapira OM, i sur.. Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner. Journal of Cellular and Molecular Medicine [Internet]. 08.2015. [pristupljeno 03.05.2024.];19(8):1887-1899. doi: 10.1111/jcmm.12561

Y. Riahi, et al., "Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner", Journal of Cellular and Molecular Medicine, vol. 19, br. 8, str. 1887-1899, Kolovoz 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:169179. [Citirano: 03.05.2024.]

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Naslov (engleski)Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner
AutorYael Riahi
AutorNurit Kaiser
AutorGuy Cohen
AutorIhab Abd-Elrahman
AutorGalia Blum
AutorOz M. Shapira
AutorTomer Koler
AutorMaya Simionescu
AutorAnca V. Sima
AutorNeven Žarković
AutorKamelija Žarković
AutorMarica Orioli
AutorGiancarlo Aldini
AutorErol Cerasi
AutorGil Leibowitz
AutorShlomo Sasson
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Vascular endothelial cell (VEC) senescence is considered an early event in the development of atherosclerotic lesions. Stressful stimuli, in particular oxidative stress, have been linked to premature senescence in the vasculature. Foam cells are a major source of reactive oxygen species and may play a role in the induction of VEC senescence; hence, we investigated their involvement in the induction of VEC senescence in a co-culture transwell system. Primary bovine aortic endothelial cells, exposed to the secretome of THP-1 monocyte-derived foam cells, were analysed for the induction of senescence. Senescence associated β-galactosidase activity and the expression of p16 and p21 were increased, whereas phosphorylated retinoblastoma protein was reduced. This senescent phenotype was mediated by 4-hydroxnonenal (4-HNE), a lipid peroxidation product secreted from foam cells; scavenging of 4-HNE in the co-culture medium blunted this effect. Furthermore, both foam cells and 4-HNE increased the expression of the pro-oxidant thioredoxin-interacting protein (TXNIP). Molecular manipulation of TXNIP expression confirmed its involvement in foam cell-induced senescence. Previous studies showed that peroxisome proliferator-activated receptor (PPAR)δ was activated by 4-hydroalkenals, such as 4-HNE. Pharmacological interventions supported the involvement of the 4-HNE-PPARδ axis in the induction of TXNIP and VEC senescence. The association of TXNIP with VEC senescence was further supported by immunofluorescent staining of human carotid plaques in which the expression of both TXNIP and p21 was augmented in endothelial cells. Collectively, these findings suggest that foam cell-released 4-HNE activates PPARδ in VEC, leading to increased TXNIP expression and consequently to senescence.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Cellular and Molecular Medicine
Brojčani podacivol. 19, br. 8, str. 1887-1899
p-ISSN1582-1838
DOIhttps://doi.org/10.1111/jcmm.12561
URN:NBNurn:nbn:hr:105:169179
Datum objave publikacije2015-08
URL dokumentahttps://doi.org/10.1111/jcmm.12561
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:36:34