prikaz prve stranice dokumenta Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine
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Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine
PLoS ONE, 10 (2015), 4; e0123454. https://doi.org/10.1371/journal.pone.0123454
Stupnišek, Mirjana; Kokot, Antonio; Drmić, Domagoj; Hrelec Patrlj, Maša; Zenko Sever, Anita; Kolenc, Danijela; Radić, Božo; Šuran, Jelena; Bojić, Davor; Včev, Aleksandar; Seiwerth, Sven; Sikirić, Predrag

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Stupnišek, M., Kokot, A., Drmić, D., Hrelec Patrlj, M., Zenko Sever, A., Kolenc, D. ... Sikirić, P. (2015). Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine. PLoS ONE, 10. (4). doi: 10.1371/journal.pone.0123454

Stupnišek, Mirjana, et al. "Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine." PLoS ONE, vol. 10, br. 4, 2015. https://doi.org/10.1371/journal.pone.0123454

Stupnišek, Mirjana, Antonio Kokot, Domagoj Drmić, Maša Hrelec Patrlj, Anita Zenko Sever, Danijela Kolenc, Božo Radić, et al. "Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine." PLoS ONE 10, br. 4 (2015). https://doi.org/10.1371/journal.pone.0123454

Stupnišek, M., et al. (2015) 'Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine', PLoS ONE, 10(4). doi: 10.1371/journal.pone.0123454

Stupnišek M, Kokot A, Drmić D, Hrelec Patrlj M, Zenko Sever A, Kolenc D, i sur.. Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine. PLoS ONE [Internet]. 21.04.2015. [pristupljeno 21.12.2024.];10(4). doi: 10.1371/journal.pone.0123454

M. Stupnišek, et al., "Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine", PLoS ONE, vol. 10, br. 4, Travanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:994955. [Citirano: 21.12.2024.]

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Naslov (engleski)Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, L-NAME and L-arginine
AutorMirjana Stupnišek
AutorAntonio Kokot
AutorDomagoj Drmić
AutorMaša Hrelec Patrlj
AutorAnita Zenko Sever
AutorDanijela Kolenc
AutorBožo Radić
AutorJelena Šuran
AutorDavor Bojić
AutorAleksandar Včev
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
BACKGROUND: BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker, L-NAME (prothrombotic) and the NOS-substrate L-arginine (antithrombotic), were little investigated. Objective. To investigate the effect of L-NAME and L-arginine on hemostatic parameters, and to reveal the effects of BPC 157 on the L-NAME- and L-arginine-induced hemostatic actions under different pathological condition: tail amputation without or with anticoagulants, heparin or warfarin. ----- METHODS: Tail amputation, and/or i.v.-heparin (10 mg/kg), i.g.-warfarin (1.5 mg/kg/day for 3 days) were used in rats. Treatment includes BPC 157, L-NAME, L-arginine, per se and their combination. ----- RESULTS: After (tail) amputation, with or without i.v.-heparin or i.g.-warfarin, BPC 157 (10 μg/kg, 10 ng/kg, i.p., i.v. (heparin), 10 μg/kg i.g. (warfarin)) always reduced bleeding time and/or haemorrhage and counteracted thrombocytopenia. As for L-NAME and/or L-arginine, we noted: L-arginine (100 mg/kg i.p.)-rats: more bleeding, less/no thrombocytopenia; L-NAME (5 mg/kg i.p.)-rats: less bleeding (amputation only), but present thrombocytopenia; L-NAME+L-arginine-rats also exhibited thrombocytopenia: L-NAME counteracted L-arginine-increased bleeding, L-arginine did not counteract L-NAME-thrombocytopenia. All animals receiving BPC 157 in addition (BPC 157 μg+L-NAME; BPC 157 μg+L-arginine, BPC 157 μg+L-NAME+L-arginine), exhibited decreased haemorrhage and markedly counteracted thrombocytopenia. ----- CONCLUSIONS: L-NAME (thrombocytopenia), L-arginine (increased haemorrhage) counteraction and BPC 157 (decreased haemorrhage, counteracted thrombocytopenia) with rescue against two different anticoagulants, implicate a BPC 157 modulatory and balancing role with rescued NO-hemostatic mechanisms.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 10, br. 4, e0123454
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0123454
URN:NBNurn:nbn:hr:105:994955
Datum objave publikacije2015-04-21
URL dokumentahttps://doi.org/10.1371/journal.pone.0123454
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:36:53