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A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics
PLoS ONE, 11 (2016), 9; e0162866. https://doi.org/10.1371/journal.pone.0162866
Mizzi, Clint; Dalabira, Eleni; Kumuthini, Judit; Dzimiri, Nduna; Balogh, Istvan; Başak, Nazli; Böhm, Ruwen; Borg, Joseph; Borgiani, Paola; Božina, Nada; Bruckmueller, Henrike; Burzynska, Beata; Carracedo, Angel; Cascorbi, Ingolf; Deltas, Constantinos; Dolzan, Vita; Fenech, Anthony; Grech, Godfrey; Kasiulevicius, Vytautas; Kádaši, Ľudevít; Kučinskas, Vaidutis; Khusnutdinova, Elza; Loukas, Yiannis L.; Macek, Milan; Makukh, Halyna; Mathijssen, Ron; Mitropoulos, Konstantinos; Mitropoulou, Christina; Novelli, Giuseppe; Papantoni, Ioanna; Pavlovic, Sonja; Saglio, Giuseppe; Sertić, Jadranka; Stojiljkovic, Maja; Stubbs, Andrew P.; Squassina, Alessio; Torres, Maria; Turnovec, Marek; van Schaik, Ron H.; Voskarides, Konstantinos; Wakil, Salma M.; Werk, Anneke; del Zompo, Maria; Zukic, Branka; Katsila, Theodora; Lee, Ming Ta Michael; Motsinger-Rief, Alison; Mc Leod, Howard L.; van der Spek, Peter J.; Patrinos, George P. Više autora...

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Mizzi, C., Dalabira, E., Kumuthini, J., Dzimiri, N., Balogh, I., Başak, N. ... Patrinos, G. P. (2016). A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics. PLoS ONE, 11. (9). doi: 10.1371/journal.pone.0162866

Mizzi, Clint, et al. "A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics." PLoS ONE, vol. 11, br. 9, 2016. https://doi.org/10.1371/journal.pone.0162866

Mizzi, Clint, Eleni Dalabira, Judit Kumuthini, Nduna Dzimiri, Istvan Balogh, Nazli Başak, Ruwen Böhm, et al. "A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics." PLoS ONE 11, br. 9 (2016). https://doi.org/10.1371/journal.pone.0162866

Mizzi, C., et al. (2016) 'A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics', PLoS ONE, 11(9). doi: 10.1371/journal.pone.0162866

Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, i sur.. A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics. PLoS ONE [Internet]. 16.09.2016. [pristupljeno 12.11.2024.];11(9). doi: 10.1371/journal.pone.0162866

C. Mizzi, et al., "A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics", PLoS ONE, vol. 11, br. 9, Rujan 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:858915. [Citirano: 12.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:858915
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Naslov (engleski)A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics
AutorClint Mizzi
AutorEleni Dalabira
AutorJudit Kumuthini
AutorNduna Dzimiri
AutorIstvan Balogh
AutorNazli Başak
AutorRuwen Böhm
AutorJoseph Borg
AutorPaola Borgiani
AutorNada Božina
AutorHenrike Bruckmueller
AutorBeata Burzynska
AutorAngel Carracedo
AutorIngolf Cascorbi
AutorConstantinos Deltas
AutorVita Dolzan
AutorAnthony Fenech
AutorGodfrey Grech
AutorVytautas Kasiulevicius
AutorĽudevít Kádaši
AutorVaidutis Kučinskas
AutorElza Khusnutdinova
AutorYiannis L. Loukas
AutorMilan Macek
AutorHalyna Makukh
AutorRon Mathijssen
AutorKonstantinos Mitropoulos
AutorChristina Mitropoulou
AutorGiuseppe Novelli
AutorIoanna Papantoni
AutorSonja Pavlovic
AutorGiuseppe Saglio
AutorJadranka Sertić
AutorMaja Stojiljkovic
AutorAndrew P. Stubbs
AutorAlessio Squassina
AutorMaria Torres
AutorMarek Turnovec
AutorRon H. van Schaik
AutorKonstantinos Voskarides
AutorSalma M. Wakil
AutorAnneke Werk
AutorMaria del Zompo
AutorBranka Zukic
AutorTheodora Katsila
AutorMing Ta Michael Lee
AutorAlison Motsinger-Rief
AutorHoward L. Mc Leod
AutorPeter J. van der Spek
AutorGeorge P. Patrinos
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 11, br. 9, e0162866
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0162866
URN:NBNurn:nbn:hr:105:858915
Datum objave publikacije2016-09-16
URL dokumentahttp://doi.org/10.1371/journal.pone.0162866
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:48:31