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Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients
PLoS ONE, 11 (2016), 6; e0157507. https://doi.org/10.1371/journal.pone.0157507
Potočnjak, Ines; Degoricija, Vesna; Trbušić, Matias; Dokoza Terešak, Sanda; Radulović, Bojana; Pregartner, Gudrun; Berghold, Andrea; Tiran, Beate; Marsche, Gunther; Frank, Saša

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Potočnjak, I., Degoricija, V., Trbušić, M., Dokoza Terešak, S., Radulović, B., Pregartner, G. ... Frank, S. (2016). Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients. PLoS ONE, 11. (6). doi: 10.1371/journal.pone.0157507

Potočnjak, Ines, et al. "Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients." PLoS ONE, vol. 11, br. 6, 2016. https://doi.org/10.1371/journal.pone.0157507

Potočnjak, Ines, Vesna Degoricija, Matias Trbušić, Sanda Dokoza Terešak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Beate Tiran, Gunther Marsche i Saša Frank. "Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients." PLoS ONE 11, br. 6 (2016). https://doi.org/10.1371/journal.pone.0157507

Potočnjak, I., et al. (2016) 'Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients', PLoS ONE, 11(6). doi: 10.1371/journal.pone.0157507

Potočnjak I, Degoricija V, Trbušić M, Dokoza Terešak S, Radulović B, Pregartner G, i sur.. Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients. PLoS ONE [Internet]. 15.06.2016. [pristupljeno 08.11.2024.];11(6). doi: 10.1371/journal.pone.0157507

I. Potočnjak, et al., "Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients", PLoS ONE, vol. 11, br. 6, Lipanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:131814. [Citirano: 08.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:131814
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Podaci o radu
Naslov (engleski)Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients
AutorInes Potočnjak
AutorVesna Degoricija
AutorMatias Trbušić
AutorSanda Dokoza Terešak
AutorBojana Radulović
AutorGudrun Pregartner
AutorAndrea Berghold
AutorBeate Tiran
AutorGunther Marsche
AutorSaša Frank
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVE: The functionality of high-density lipoprotein (HDL) is impaired in chronic ischaemic heart failure (HF). However, the relationship between HDL functionality and outcomes in acute HF (AHF) has not been studied. The present study investigates whether the metrics of HDL functionality, including HDL cholesterol efflux capacity and HDL-associated paraoxonase (PON)-1 arylesterase (AE) activity are associated with hospital mortality in AHF patients. ----- METHODS AND RESULTS: The study was performed as a prospective, single-centre, observational research on 152 patients, defined and categorised according to the ESC and ACCF/AHA Guidelines for HF by time of onset, final clinical presentation and ejection fraction. The mean age of the included patients (52% female) was 75.2 years (SD 10.3) and hospital mortality was 14.5%. HDL cholesterol efflux capacity was examined by measuring the capacity of apoB depleted serum to remove tritium-labelled cholesterol from cultured macrophages. The AE activity of the HDL fraction was examined by a photometric assay. In a univariable regression analysis, low cholesterol efflux, but not AE activity, was significantly associated with hospital mortality [odds ratio (OR) 0.78, 95% confidence interval (CI) 0.64-0.96, p = 0.019]. In multivariable analysis progressively adjusting for important clinical and laboratory parameters the association obtained for cholesterol efflux capacity and hospital mortality by univariable analysis, despite a stable OR, did not stay significant (p = 0.179). ----- CONCLUSION: Our results suggest that HDL cholesterol efflux capacity (but not AE activity) contributes to, but is not an independent risk factor for, hospital mortality in AHF patients. Larger studies are needed to draw firm conclusions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 11, br. 6, e0157507
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0157507
URN:NBNurn:nbn:hr:105:131814
Datum objave publikacije2016-06-15
URL dokumentahttps://doi.org/10.1371/journal.pone.0157507
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:50:11