prikaz prve stranice dokumenta Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas
  Preuzmi
PDF 1.24 MB
Znanstveni rad - Izvorni znanstveni rad
Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas
PLoS ONE, 11 (2016), 9; e0162437. https://doi.org/10.1371/journal.pone.0162437
Reimondo, Giuseppe; Chiodini, Iacopo; Puglisi, Soraya; Pia, Anna; Morelli, Valentina; Kaštelan, Darko; Cannavo, Salvatore; Berchialla, Paola; Giachino, Daniela; Perotti, Paola; Cuccurullo, Alessandra; Paccotti, Piero; Beck-Peccoz, Paolo; De Marchi, Mario; Terzolo, Massimo Više autora...

Citirajte ovaj rad

Reimondo, G., Chiodini, I., Puglisi, S., Pia, A., Morelli, V., Kaštelan, D. ... Terzolo, M. (2016). Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas. PLoS ONE, 11. (9). doi: 10.1371/journal.pone.0162437

Reimondo, Giuseppe, et al. "Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas." PLoS ONE, vol. 11, br. 9, 2016. https://doi.org/10.1371/journal.pone.0162437

Reimondo, Giuseppe, Iacopo Chiodini, Soraya Puglisi, Anna Pia, Valentina Morelli, Darko Kaštelan, Salvatore Cannavo, et al. "Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas." PLoS ONE 11, br. 9 (2016). https://doi.org/10.1371/journal.pone.0162437

Reimondo, G., et al. (2016) 'Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas', PLoS ONE, 11(9). doi: 10.1371/journal.pone.0162437

Reimondo G, Chiodini I, Puglisi S, Pia A, Morelli V, Kaštelan D, i sur.. Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas. PLoS ONE [Internet]. 20.09.2016. [pristupljeno 12.04.2024.];11(9). doi: 10.1371/journal.pone.0162437

G. Reimondo, et al., "Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas", PLoS ONE, vol. 11, br. 9, Rujan 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:514785. [Citirano: 12.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:514785
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Analysis of BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene in adrenal incidentalomas
AutorGiuseppe Reimondo
AutorIacopo Chiodini
AutorSoraya Puglisi
AutorAnna Pia
AutorValentina Morelli
AutorDarko Kaštelan
AutorSalvatore Cannavo
AutorPaola Berchialla
AutorDaniela Giachino
AutorPaola Perotti
AutorAlessandra Cuccurullo
AutorPiero Paccotti
AutorPaolo Beck-Peccoz
AutorMario De Marchi
AutorMassimo Terzolo
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
CONTEXT: Patients with adrenal incidentalomas (AI) may experience detrimental consequences due to a minimal cortisol excess sustained by adrenal adenoma. SNPs of the glucocorticoid receptor gene (NR3C1) modulate individual sensitivity to glucocorticoids and may interfere with the clinical presentation. ----- OBJECTIVE: To compare the frequency of N363S, ER22/23EK and BclI SNPs in patients with AI with the general population and to evaluate whether these SNPs are linked to consequences of cortisol excess. ----- SETTING: Multicentric, retrospective analysis of patients referred from 2010 to 2014 to 4 centers (Orbassano, Milano, Messina [Italy] and Zagreb [Croatia]). ----- PATIENTS: 411 patients with AI; 153 males and 258 females and 186 from blood donors. ----- MAIN OUTCOMES MEASURES: All patients and controls were genotyped for BclI, N363S and ER22/23EK and SNPs frequency was associated with clinical and hormonal features. ----- RESULTS: SNP frequency was: SNP frequency was: N363S 5.4% (MAF 0.027), BclI 54.7% (MAF 0.328), ER22/23EK 4.4% (MAF 0.022), without any significant difference between patients and controls. N363S was more frequent in hypertensive patients (p = 0.03) and was associated with hypertension (p = 0.015) in patients with suppressed cortisol after the 1-mg DST. ----- CONCLUSIONS: Our results demonstrate that SNPs of the glucocorticoid receptor gene do not play a pathogenetic role for AI. The impact of any single SNP on the phenotypic expression of minimal cortisol excess is limited and their analysis does not provide additional data that may be exploited for patient management.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 11, br. 9, e0162437
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0162437
URN:NBNurn:nbn:hr:105:514785
Datum objave publikacije2016-09-20
URL dokumentahttp://doi.org/10.1371/journal.pone.0162437
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:51:01