prikaz prve stranice dokumenta Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure
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Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure
EBioMedicine, 7 (2016); 221-229. https://doi.org/10.1016/j.ebiom.2016.03.020
Rosenzweig, Ivana; Glasser, Martin; Crum, William R.; Kempton, Matthew J.; Milošević, Milan; McMillan, Alison; Leschziner, Guy D.; Kumari, Veena; Goadsby, Peter; Simonds, Anita K.; Williams, Steve C.R.; Morrell, Mary J.

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Rosenzweig, I., Glasser, M., Crum, W. R., Kempton, M. J., Milošević, M., McMillan, A. ... Morrell, M. J. (2016). Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure. EBioMedicine, 7., 221-229. doi: 10.1016/j.ebiom.2016.03.020

Rosenzweig, Ivana, et al. "Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure." EBioMedicine, vol. 7, 2016, str. 221-229. https://doi.org/10.1016/j.ebiom.2016.03.020

Rosenzweig, Ivana, Martin Glasser, William R. Crum, Matthew J. Kempton, Milan Milošević, Alison McMillan, Guy D. Leschziner, et al. "Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure." EBioMedicine 7 (2016): 221-229. https://doi.org/10.1016/j.ebiom.2016.03.020

Rosenzweig, I., et al. (2016) 'Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure', EBioMedicine, 7, str. 221-229. doi: 10.1016/j.ebiom.2016.03.020

Rosenzweig I, Glasser M, Crum WR, Kempton MJ, Milošević M, McMillan A, i sur.. Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure. EBioMedicine [Internet]. 07.05.2016. [pristupljeno 08.11.2024.];7:221-229. doi: 10.1016/j.ebiom.2016.03.020

I. Rosenzweig, et al., "Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure", EBioMedicine, vol. 7, str. 221-229, Svibanj 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:381256. [Citirano: 08.11.2024.]

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Naslov (engleski)Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure
AutorIvana Rosenzweig
AutorMartin Glasser
AutorWilliam R. Crum
AutorMatthew J. Kempton
AutorMilan Milošević
AutorAlison McMillan
AutorGuy D. Leschziner
AutorVeena Kumari
AutorPeter Goadsby
AutorAnita K. Simonds
AutorSteve C.R. Williams
AutorMary J. Morrell
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
BACKGROUND: Obstructive sleep apnea (OSA) is a chronic, multisystem disorder that has a bidirectional relationship with several major neurological disorders, including Alzheimer's dementia. Treatment with Continuous Positive Airway Pressure (CPAP) offers some protection from the effects of OSA, although it is still unclear which populations should be targeted, for how long, and what the effects of treatment are on different organ systems. We investigated whether cognitive improvements can be achieved as early as one month into CPAP treatment in patients with OSA. ----- METHODS: 55 patients (mean (SD) age: 47.6 (11.1) years) with newly diagnosed moderate-severe OSA (Oxygen Desaturation Index: 36.6 (25.2) events/hour; Epworth sleepiness score (ESS): 12.8 (4.9)) and 35 matched healthy volunteers were studied. All participants underwent neurocognitive testing, neuroimaging and polysomnography. Patients were randomized into parallel groups: CPAP with best supportive care (BSC), or BSC alone for one month, after which they were re-tested. ----- FINDINGS: One month of CPAP with BSC resulted in a hypertrophic trend in the right thalamus [mean difference (%): 4.04, 95% CI: 1.47 to 6.61], which was absent in the BSC group [-2.29, 95% CI: -4.34 to -0.24]. Significant improvement was also recorded in ESS, in the CPAP plus BSC group, following treatment [mean difference (%): -27.97, 95% CI: -36.75 to -19.19 vs 2.46, 95% CI: -5.23 to 10.15; P=0.012], correlated to neuroplastic changes in brainstem (r=-0.37; P=0.05), and improvements in delayed logical memory scores [57.20, 95% CI: 42.94 to 71.46 vs 23.41, 95% CI: 17.17 to 29.65; P=0.037]. ----- INTERPRETATION: One month of CPAP treatment can lead to adaptive alterations in the neurocognitive architecture that underlies the reduced sleepiness, and improved verbal episodic memory in patients with OSA. We propose that partial neural recovery occurs during short periods of treatment with CPAP.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEBioMedicine
Brojčani podacivol. 7, str. 221-229
p-ISSN2352-3964
DOIhttps://doi.org/10.1016/j.ebiom.2016.03.020
URN:NBNurn:nbn:hr:105:381256
Datum objave publikacije2016-05-07
URL dokumentahttps://doi.org/10.1016/j.ebiom.2016.03.020
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:50:43