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The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation
International Journal of Hematology, 102 (2015), 1; 12-24. https://doi.org/10.1007/s12185-015-1776-2
Dembitz, Vilma; Lalić, Hrvoje; Ostojić, Alen; Vrhovac, Radovan; Banfić, Hrvoje; Višnjić, Dora

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Dembitz, V., Lalić, H., Ostojić, A., Vrhovac, R., Banfić, H. i Višnjić, D. (2015). The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. International Journal of Hematology, 102. (1), 12-24. doi: 10.1007/s12185-015-1776-2

Dembitz, Vilma, et al. "The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation." International Journal of Hematology, vol. 102, br. 1, 2015, str. 12-24. https://doi.org/10.1007/s12185-015-1776-2

Dembitz, Vilma, Hrvoje Lalić, Alen Ostojić, Radovan Vrhovac, Hrvoje Banfić i Dora Višnjić. "The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation." International Journal of Hematology 102, br. 1 (2015): 12-24. https://doi.org/10.1007/s12185-015-1776-2

Dembitz, V., et al. (2015) 'The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation', International Journal of Hematology, 102(1), str. 12-24. doi: 10.1007/s12185-015-1776-2

Dembitz V, Lalić H, Ostojić A, Vrhovac R, Banfić H, Višnjić D. The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. International Journal of Hematology [Internet]. 07.2015. [pristupljeno 11.04.2024.];102(1):12-24. doi: 10.1007/s12185-015-1776-2

V. Dembitz, H. Lalić, A. Ostojić, R. Vrhovac, H. Banfić i D. Višnjić, "The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation", International Journal of Hematology, vol. 102, br. 1, str. 12-24, Srpanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:118218. [Citirano: 11.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:118218
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Naslov (engleski)The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation
AutorVilma Dembitz
AutorHrvoje Lalić
AutorAlen Ostojić
AutorRadovan Vrhovac
AutorHrvoje Banfić
AutorDora Višnjić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Arsenic trioxide (ATO) has potent clinical activity in the treatment of patients with acute promyelocytic leukemia (APL), but is much less efficacious in acute myeloid leukemia (AML) lacking t(15;17) translocation. Recent studies have indicated that the addition of mammalian target of rapamycin (mTOR) inhibitors may increase the sensitivity of malignant cells to ATO. The aim of the present study was to test for possible synergistic effects of ATO and rapamycin at therapeutically achievable doses in non-APL AML cells. In HL-60 and U937 cell lines, the inhibitory effects of low concentrations of ATO and rapamycin were synergistic and more pronounced in U937 cells. The combination of drugs increased apoptosis in HL-60 cells and increased the percentage of cells in G(0)/G(1) phase in both cell lines. In U937 cells, rapamycin alone increased the activity of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and the addition of ATO decreased the level of phosphorylated ERK, Ser473 phosphorylated Akt and anti-apoptotic Mcl-1 protein. Primary AML cells show high sensitivity to growth-inhibitory effects of rapamycin alone or in combination with ATO. The results of the present study reveal the mechanism of the synergistic effects of two drugs at therapeutically achievable doses in non-APL AML cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Journal of Hematology
Brojčani podacivol. 102, br. 1, str. 12-24
p-ISSN0925-5710
DOIhttps://doi.org/10.1007/s12185-015-1776-2
URN:NBNurn:nbn:hr:105:118218
Datum objave publikacije2015-07
URL dokumentahttps://doi.org/10.1007/s12185-015-1776-2
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:54:53