prikaz prve stranice dokumenta Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats
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Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats
PLoS ONE, 11 (2016), 2; e0150102. https://doi.org/10.1371/journal.pone.0150102
Erjavec, Igor; Bordukalo-Nikšić, Tatjana; Brkljačić, Jelena; Grčević, Danka; Mokrović, Gordana; Kesić, Maja; Rogić, Dunja; Zavadoski, William; Paralkar, Vishwas M.; Grgurević, Lovorka; Trkulja, Vladimir; Čičin-Šain, Lipa; Vukičević, Slobodan

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Erjavec, I., Bordukalo Nikšić, T., Brkljačić, J., Grčević, D., Mokrović, G., Kesić, M. ... Vukičević, S. (2016). Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats. PLoS ONE, 11. (2). doi: 10.1371/journal.pone.0150102

Erjavec, Igor, et al. "Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats." PLoS ONE, vol. 11, br. 2, 2016. https://doi.org/10.1371/journal.pone.0150102

Erjavec, Igor, Tatjana Bordukalo Nikšić, Jelena Brkljačić, Danka Grčević, Gordana Mokrović, Maja Kesić, Dunja Rogić, et al. "Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats." PLoS ONE 11, br. 2 (2016). https://doi.org/10.1371/journal.pone.0150102

Erjavec, I., et al. (2016) 'Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats', PLoS ONE, 11(2). doi: 10.1371/journal.pone.0150102

Erjavec I, Bordukalo Nikšić T, Brkljačić J, Grčević D, Mokrović G, Kesić M, i sur.. Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats. PLoS ONE [Internet]. 23.02.2016. [pristupljeno 15.04.2024.];11(2). doi: 10.1371/journal.pone.0150102

I. Erjavec, et al., "Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats", PLoS ONE, vol. 11, br. 2, Veljača 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:297045. [Citirano: 15.04.2024.]

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Naslov (engleski)Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats
AutorIgor Erjavec
AutorTatjana Bordukalo-Nikšić
AutorJelena Brkljačić
AutorDanka Grčević
AutorGordana Mokrović
AutorMaja Kesić
AutorDunja Rogić
AutorWilliam Zavadoski
AutorVishwas M. Paralkar
AutorLovorka Grgurević
AutorVladimir Trkulja
AutorLipa Čičin-Šain
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption. The role of 5HT in bone therefore remains poorly understood. To address this issue, we used selective breeding to create rat sublines with constitutively high (high-5HT) and low (low-5HT) platelet 5HT level (PSL) and platelet 5HT uptake (PSU). High-5HT rats had decreased bone volume due to increased bone turnover characterized by increased bone formation and mineral apposition rate, increased osteoclast number and serum C-telopeptide level. Daily oral administration of the TPH1 inhibitor (LX1032) for 6 weeks reduced PSL and increased the trabecular bone volume and trabecular number of the spine and femur in high-5HT rats. High-5HT animals also developed a type 2 diabetes (T2D) phenotype with increased: plasma insulin, glucose, hemoglobin A1c, body weight, visceral fat, β-cell pancreatic islets size, serum cholesterol, and decreased muscle strength. Serum calcium accretion mediated by parathyroid hormone slightly increased, whereas treatment with 1,25(OH)2D3 decreased PSL. Insulin reduction was paralleled by a drop in PSL in high-5HT rats. In vitro, insulin and 5HT synergistically up-regulated osteoblast differentiation isolated from high-5HT rats, whereas TPH1 inhibition decreased the number of bone marrow-derived osteoclasts. These results suggest that constitutively elevated PSL is associated with bone loss and T2D via a homeostatic interplay between the peripheral 5HT, bone and insulin.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPLoS ONE
Brojčani podacivol. 11, br. 2, e0150102
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0150102
URN:NBNurn:nbn:hr:105:297045
Datum objave publikacije2016-02-23
URL dokumentahttp://doi.org/10.1371/journal.pone.0150102
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:56:49