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The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection
Microbial Pathogenesis, 97 (2016); 125-30. https://doi.org/10.1016/j.micpath.2016.06.008
Gorenec, Lana; Židovec Lepej, Snježana; Grgić, Ivana; Planinić, Ana; Iščić Beš, Janja; Vince, Adriana; Begovac, Josip

Citirajte ovaj rad

Gorenec, L., Židovec Lepej, S., Grgić, I., Planinić, A., Iščić Beš, J., Vince, A. i Begovac, J. (2016). The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection. Microbial Pathogenesis, 97., 125-30. doi: 10.1016/j.micpath.2016.06.008

Gorenec, Lana, et al. "The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection." Microbial Pathogenesis, vol. 97, 2016, str. 125-30. https://doi.org/10.1016/j.micpath.2016.06.008

Gorenec, Lana, Snježana Židovec Lepej, Ivana Grgić, Ana Planinić, Janja Iščić Beš, Adriana Vince i Josip Begovac. "The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection." Microbial Pathogenesis 97 (2016): 125-30. https://doi.org/10.1016/j.micpath.2016.06.008

Gorenec, L., et al. (2016) 'The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection', Microbial Pathogenesis, 97, str. 125-30. doi: 10.1016/j.micpath.2016.06.008

Gorenec L, Židovec Lepej S, Grgić I, Planinić A, Iščić Beš J, Vince A, i sur.. The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection. Microbial Pathogenesis [Internet]. 08.2016. [pristupljeno 07.11.2024.];97:125-30. doi: 10.1016/j.micpath.2016.06.008

L. Gorenec, et al., "The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection", Microbial Pathogenesis, vol. 97, str. 125-30, Kolovoz 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:186418. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:186418
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Podaci o radu
Naslov (engleski)The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection
AutorLana Gorenec
AutorSnježana Židovec Lepej
AutorIvana Grgić
AutorAna Planinić
AutorJanja Iščić Beš
AutorAdriana Vince
AutorJosip Begovac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The aim of this study was to compare cytokine expression on both gene and protein levels in acute and chronic phase of HIV type 1 (HIV-1) infection. Thirty four patients were enrolled for cytokine expression analysis on protein level in acute and chronic stage of HIV-1 infection. Using PCR array technology, expression of 84 cytokine genes was measured in 3 patients in acute and 3 patients in chronic stage of HIV-1 infection. Bead-based cytometry was used to quantify levels of Th1/Th2/Th9/Th17/Th22 cytokines. The results showed statistically significant increase of 13 cytokine gene expression (cd40lg, csf2, ifna5, il12b, il1b, il20, lta, osm, spp1, tgfa, tnfsf 11, 14 and 8) and downregulation of the il12a expression in chronic HIV type 1 infection. Concentrations of IL-10, IL-4 and TNF-α were increased in the acute HIV type 1 infection when compared to control group. During chronic HIV type 1 infection there was an increase of IL-10, TNF-α, IL-2, IL-6, IL-13 and IL-22 levels when compared to control group. Comparison of cytokine expression between two stages of infection showed a significant decrease in IL-9 concentration. This study showed changes in cytokine profiles on both gene and protein levels in different stages of HIV-infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaMicrobial Pathogenesis
Brojčani podacivol. 97, str. 125-30
p-ISSN0882-4010
DOIhttps://doi.org/10.1016/j.micpath.2016.06.008
URN:NBNurn:nbn:hr:105:186418
Datum objave publikacije2016-08
URL dokumentahttp://doi.org/10.1016/j.micpath.2016.06.008
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 08:56:19