Combined ovulation triggering with GnRH agonist and hCG in IVF patients

Znanstveni rad - Pregledni rad

• Autor: Miro Kasum
• Autor: Kristijan Kurdija
• Autor: Slavko Orešković
• Autor: Ermin Čehić
• Autor: Dinka Pavičić-Baldani
• Autor: Lana Škrgatić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

The aim of the review is to analyse the combination of a gonadotrophin releasing hormone (GnRH) agonist with a human chorionic gonadotrophin (hCG) trigger, for final oocyte maturation in in vitro fertilisation (IVF) cycles. The concept being a ''dual trigger'' combines a single dose of the GnRH agonist with a reduced or standard dosage of hCG at the time of triggering. The use of a GnRH agonist with a reduced dose of hCG in high responders demonstrated luteal phase support with improved pregnancy rates, similar to those after conventional hCG and a low risk of ovarian hyperstimulation syndrome (OHSS). The administration of a GnRH agonist and a standard hCG in normal responders, demonstrated significantly improved live-birth rates and a higher number of embryos of excellent quality, or cryopreserved embryos. The concept of the ''double trigger" represents a combination of a GnRH agonist and a standard hCG, when used 40 and 34 h prior to ovum pick-up, respectively. The use of the ''double trigger" has been successfully offered in the treatment of empty follicle syndrome and in patients with a history of immature oocytes retrieved or with low/poor oocytes yield. Further prospective studies are required to confirm the aforementioned observations prior to clinical implementation.

• Ključne riječi (engleski): Adult; Chorionic Gonadotropin/administration & dosage; Chorionic Gonadotropin/pharmacology; Drug Therapy, Combination; Female; Fertilization in Vitro/methods; Gonadotropin-Releasing Hormone/administration & dosage; Gonadotropin-Releasing Hormone/agonists; Gonadotropin-Releasing Hormone/pharmacology; Humans; Ovulation Induction/methods
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Gynecological Endocrinology
• Brojčani podaci: vol. 32, br. 11, str. 861-865
• p-ISSN: 0951-3590
• DOI: https://doi.org/10.1080/09513590.2016.1193141
• URN:NBN: urn:nbn:hr:105:785251
• Datum objave publikacije: 2016-11
• URL dokumenta: http://doi.org/10.1080/09513590.2016.1193141
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 08:58:14