prikaz prve stranice dokumenta The degree of anisocytosis predicts survival in patients with primary myelofibrosis
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The degree of anisocytosis predicts survival in patients with primary myelofibrosis
Acta Haematologica, 136 (2016), 2; 98-100. https://doi.org/10.1159/000445247
Lucijanić, Marko; Pejša, Vlatko; Jakšić, Ozren; Mitrović, Zdravko; Tomasović-Lončarić, Čedna; Štoos-Veić, Tajana; Prka, Željko; Piršić, Mario; Hariš, Višnja; Vasilj, Tamara; Kušec, Rajko

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Lucijanić, M., Pejša, V., Jakšić, O., Mitrović, Z., Tomasović Lončarić, Č., Štoos Veić, T. ... Kušec, R. (2016). The degree of anisocytosis predicts survival in patients with primary myelofibrosis. Acta Haematologica, 136. (2), 98-100. doi: 10.1159/000445247

Lucijanić, Marko, et al. "The degree of anisocytosis predicts survival in patients with primary myelofibrosis." Acta Haematologica, vol. 136, br. 2, 2016, str. 98-100. https://doi.org/10.1159/000445247

Lucijanić, Marko, Vlatko Pejša, Ozren Jakšić, Zdravko Mitrović, Čedna Tomasović Lončarić, Tajana Štoos Veić, Željko Prka, et al. "The degree of anisocytosis predicts survival in patients with primary myelofibrosis." Acta Haematologica 136, br. 2 (2016): 98-100. https://doi.org/10.1159/000445247

Lucijanić, M., et al. (2016) 'The degree of anisocytosis predicts survival in patients with primary myelofibrosis', Acta Haematologica, 136(2), str. 98-100. doi: 10.1159/000445247

Lucijanić M, Pejša V, Jakšić O, Mitrović Z, Tomasović Lončarić Č, Štoos Veić T, i sur.. The degree of anisocytosis predicts survival in patients with primary myelofibrosis. Acta Haematologica [Internet]. 2016. [pristupljeno 27.04.2024.];136(2):98-100. doi: 10.1159/000445247

M. Lucijanić, et al., "The degree of anisocytosis predicts survival in patients with primary myelofibrosis", Acta Haematologica, vol. 136, br. 2, str. 98-100, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:239210. [Citirano: 27.04.2024.]

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Naslov (engleski)The degree of anisocytosis predicts survival in patients with primary myelofibrosis
AutorMarko Lucijanić
AutorVlatko Pejša
AutorOzren Jakšić
AutorZdravko Mitrović
AutorČedna Tomasović-Lončarić
AutorTajana Štoos-Veić
AutorŽeljko Prka
AutorMario Piršić
AutorVišnja Hariš
AutorTamara Vasilj
AutorRajko Kušec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Introduction: Red cell distribution width (RDW) provides a quantitative measure of anisocytosis and it is associated with the presence of subclinical systemic inflammation and a poor outcome in a variety of diseases when elevated. Anisocytosis is a feature of primary myelofibrosis (PMF) but it’s prognostic role in PMF has not yet been evaluated. ----- Patients and methods: 33 newly-diagnosed patients with PMF were analyzed. Baseline RDW values were obtained in addition to CRP, LDH, complete blood count, iron metabolism parameters and JAK2 V617F mutational status. Patients were staged according to IPSS prognostic scoring system, liver and spleen size were assessed by palpation. ----- Results: Median RDW was 19.0% (15.2%-22.5%). RDW correlated significantly with hemoglobin level (p=0.005), CRP (p=0.031), spleen size (p=0.036) and IPSS score (p=0.003). Patients with more pronounced anisocytosis had an inferior overall survival (OS) – very-high RDW (≥19.0%) vs. high RDW (15.1%-18.9%) subgroup, HR 5.37, p=0.002. RDW remained significantly associated with OS (p=0.002) in a multivariate model including IPSS score, hemoglobin level and CRP. ----- Conclusion: A higher degree of anisocytosis is associated with more advanced disease features and a decreased overall survival. RDW encompasses standard prognostic score and may help in the rapid detection of patients with an unfavorable prognosis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Haematologica
Brojčani podacivol. 136, br. 2, str. 98-100
p-ISSN0001-5792
DOIhttps://doi.org/10.1159/000445247
URN:NBNurn:nbn:hr:105:239210
Datum objave publikacije2016
URL dokumentahttps://doi.org/10.1159/000445247
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:57:55