Evaluating the role of hormone therapy in postmenopausal women with Alzheimer's disease

Znanstveni rad - Pregledni rad

• Autor: Jelena Osmanović-Barilar
• Autor: Melita Šalković-Petrišić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti

Sažetak (engleski)

Hormone therapy (HT) is prescribed during or after menopausal transition to replace the decline in estrogen and progesterone levels. While some studies indicate that estrogen and progesterone depletion in postmenopausal women might carry a significant risk for developing sporadic Alzheimer's disease (sAD), which may be reduced by HT, recent clinical trials oppose this beneficial effect. This review points to possible reasons for these mixed data by considering the issues of both preclinical and clinical trials, in particular, the representativeness of animal models, timing of HT initiation, type of HT (different types of estrogen compounds, estrogen monotherapy vs. estrogen-progesterone combined therapy), mode of drug delivery (subcutaneous, transdermal, oral, or intramuscular), and hormone dosage used, as well as the heterogeneity of the postmenopausal population in clinical trials (particularly considering their sAD stage, anti-AD therapy, and hysterectomy status). Careful planning of future preclinical and clinical HT interventional studies might help to elucidate the effect of HT on cognitive status in postmenopausal women with sAD, which will eventually contribute to more effective sAD prevention and treatment.

• Ključne riječi (engleski): Alzheimer Disease/blood; Alzheimer Disease/drug therapy; Alzheimer Disease/psychology; Animals; Apolipoproteins E/metabolism; Clinical Trials as Topic; Cognition/drug effects; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Replacement Therapy/methods; Estrogens/administration & dosage; Estrogens/adverse effects; Estrogens/blood; Estrogens/therapeutic use; Female; Humans; Memory/drug effects; Postmenopause/metabolism; Postmenopause/psychology; Progesterone/administration & dosage; Progesterone/adverse effects; Progesterone/blood; Progesterone/therapeutic use
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Drugs & Aging
• Brojčani podaci: vol. 33, br. 11, str. 787-808
• p-ISSN: 1170-229X
• DOI: https://doi.org/10.1007/s40266-016-0407-9
• URN:NBN: urn:nbn:hr:105:631932
• Datum objave publikacije: 2016-11
• URL dokumenta: https://doi.org/10.1007/s40266-016-0407-9
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 08:59:54