prikaz prve stranice dokumenta Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
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Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
Haematologica, 102 (2017), 8; 1361-1367. https://doi.org/10.3324/haematol.2017.167080
Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Tobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjørn Tore Više autora...

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Gullaksen, S. E., Skavland, J., Gavasso, S., Tosevski, V., Warzocha, K., Dumrese, C. ... Gjertsen, B. T. (2017). Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. Haematologica, 102. (8), 1361-1367. doi: 10.3324/haematol.2017.167080

Gullaksen, Stein Erik, et al. "Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib." Haematologica, vol. 102, br. 8, 2017, str. 1361-1367. https://doi.org/10.3324/haematol.2017.167080

Gullaksen, Stein Erik, Jørn Skavland, Sonia Gavasso, Vinko Tosevski, Krzysztof Warzocha, Claudia Dumrese, Augustin Ferrant, et al. "Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib." Haematologica 102, br. 8 (2017): 1361-1367. https://doi.org/10.3324/haematol.2017.167080

Gullaksen, S. E., et al. (2017) 'Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib', Haematologica, 102(8), str. 1361-1367. doi: 10.3324/haematol.2017.167080

Gullaksen SE, Skavland J, Gavasso S, Tosevski V, Warzocha K, Dumrese C, i sur.. Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. Haematologica [Internet]. 08.2017. [pristupljeno 02.05.2024.];102(8):1361-1367. doi: 10.3324/haematol.2017.167080

S. E. Gullaksen, et al., "Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib", Haematologica, vol. 102, br. 8, str. 1361-1367, Kolovoz 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:821605. [Citirano: 02.05.2024.]

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Naslov (engleski)Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
AutorStein-Erik Gullaksen
AutorJørn Skavland
AutorSonia Gavasso
AutorVinko Tosevski
AutorKrzysztof Warzocha
AutorClaudia Dumrese
AutorAugustin Ferrant
AutorTobias Gedde-Dahl
AutorAndrzej Hellmann
AutorJeroen Janssen
AutorBoris Labar
AutorAlois Lang
AutorWaleed Majeed
AutorGeorgi Mihaylov
AutorJesper Stentoft
AutorLeif Stenke
AutorJosef Thaler
AutorNoortje Thielen
AutorGregor Verhoef
AutorJaroslava Voglova
AutorGert Ossenkoppele
AutorAndreas Hochhaus
AutorHenrik Hjorth-Hansen
AutorSatu Mustjoki
AutorSieghart Sopper
AutorFrancis Giles
AutorKimmo Porkka
AutorDominik Wolf
AutorBjørn Tore Gjertsen
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete mass cytometry analysis pipeline for characterization of intracellular signal transduction patterns in the major leukocyte subsets of chronic phase chronic myeloid leukemia. Changes in phosphorylated Bcr-Abl1 and the signaling pathways involved were readily identifiable in peripheral blood single cells already within three hours of the patient receiving oral nilotinib. The signal transduction profiles of healthy donors were clearly distinct from those of the patients at diagnosis. Furthermore, using principal component analysis, we could show that phosphorylated transcription factors STAT3 (Y705) and CREB (S133) within seven days reflected BCR-ABL1IS at three and six months. Analyses of peripheral blood cells longitudinally collected from patients in the ENEST1st clinical trial showed that single cell mass cytometry appears to be highly suitable for future investigations addressing tyrosine kinase inhibitor dosing and effect.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaHaematologica
Brojčani podacivol. 102, br. 8, str. 1361-1367
p-ISSN0390-6078
DOIhttps://doi.org/10.3324/haematol.2017.167080
URN:NBNurn:nbn:hr:105:821605
Datum objave publikacije2017-08
URL dokumentahttps://doi.org/10.3324/haematol.2017.167080
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:07:46