Helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease

Znanstveni rad - Izvorni znanstveni rad

• Autor: Anita Jukić
• Autor: Dorotea Božić
• Autor: Duško Kardum
• Autor: Tina Bečić
• Autor: Bruno Lukšić
• Autor: Mislav Vrsalović
• Autor: Marko Ljubković
• Autor: Damir Fabijanić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

AIM:

Controversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). We aimed to examine the relationship between HP infection and severity of coronary atherosclerosis in patients with chronic CAD. -----
PATIENTS AND METHODS:
A total of 150 patients (109 [73%] men; mean age 62.61±10.23 years) scheduled for coronary artery bypass grafting surgery were consecutively enrolled in the cross-sectional study. According to rapid urease test and/or gastric biopsy samples stained with hematoxylin and eosin and according to Giemsa, patients were classified as HP positive (n=87; 58%) or HP negative (n=63; 42%). Coronary angiograms were scored by quantitative assessment, using multiple angiographic scoring system: 1) vessel score (number of coronary arteries stenosed ≥50%), 2) Gensini score (assigning a severity score to each coronary stenosis according to the degree of luminal narrowing and its topographic importance) and 3) angiographic severity score (number of coronary artery segments stenosed ≥50%). -----

RESULTS:

In comparison to HP-negative patients, HP-positive patients were more frequently hypertensive (P=0.014), had higher values of systolic (P=0.043) and diastolic (P=0.005) blood pressure and total cholesterol (P=0.013) and had lower values of high-density lipoprotein-cholesterol (HDL-C; P=0.010). There were no significant differences between the groups in the severity of coronary atherosclerosis: vessel score (P=0.152), Gensini score (P=0.870) and angiographic severity score (P=0.734). -----

CONCLUSION:

It is likely that HP infection is not a risk factor for the severity of coronary atherosclerosis in chronic CAD patients.

• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Therapeutics and Clinical Risk Management
• Brojčani podaci: vol. 13, str. 933-938
• p-ISSN: 1178-203X
• DOI: https://doi.org/10.2147/TCRM.S142193
• URN:NBN: urn:nbn:hr:105:866181
• Datum objave publikacije: 2017-07-27
• URL dokumenta: https://doi.org/10.2147/TCRM.S142193
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 09:08:13