IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis

Znanstveni rad - Izvorni znanstveni rad

• Autor: Arijana Pačić
• Autor: Petar Šenjug
• Autor: Jasna Bacalja
• Autor: Miroslav Tišljar
• Autor: Ivica Horvatić
• Autor: Stela Bulimbašić
• Autor: Mladen Knotek
• Autor: Krešimir Galešić
• Autor: Danica Galešić Ljubanović
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

AIM:

To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS). -----

METHODS:

Kidney biopsy specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50 control patients were retrospectively included in the study. For each patient, clinical and outcome data were obtained and compared to morphological parameters, including immunofluorescence analysis of mesangial IgM and complement 3 (C3) deposits analyzed on kidney biopsy samples. -----

RESULTS:

There were significant positive correlations between IgM and C3 deposition in secondary FSGS (P<0.001) and between IgM and mesangial deposits detected by electron microscopy in secondary FSGS (P=0.015), which indicated that higher IgM deposition correlated with higher C3 deposition and mesangial deposits only in secondary FSGS. Patients with secondary FSGS and the deposition of IgM showed inferior renal outcomes at earlier time points in comparison with patients with negative IgM expression (P=0.022). -----

CONCLUSIONS:

We detected a positive correlation between IgM and C3 in secondary FSGS. The association between IgM deposition and worse renal outcome in secondary FSGS indicates that IgM may play a role in the progression of this disease.

• Ključne riječi (engleski): Adolescent; Adult; Biomarkers/metabolism; Case-Control Studies; Complement C3/metabolism; Disease Progression; Female; Glomerulosclerosis, Focal Segmental/immunology; Glomerulosclerosis, Focal Segmental/pathology; Humans; Immunoglobulin M/metabolism; Kidney/metabolism; Kidney/pathology; Male; Mesangial Cells/metabolism; Mesangial Cells/pathology; Middle Aged; Retrospective Studies
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Croatian Medical Journal
• Brojčani podaci: vol. 58, br. 4, str. 281-291
• p-ISSN: 0353-9504
• DOI: https://doi.org/10.3325/cmj.2017.58.281
• URN:NBN: urn:nbn:hr:105:114917
• Datum objave publikacije: 2017-08-31
• URL dokumenta: https://doi.org/10.3325/cmj.2017.58.281
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 09:10:17