prikaz prve stranice dokumenta Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report
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Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report
BMC Neurology, 17 (2017); 102. https://doi.org/10.1186/s12883-017-0877-3
Wallin, Anders; Kapaki, Elisabeth; Boban, Marina; Engelborghs, Sebastian; Hermann, Dirk Matthias; Huisa, Branko; Jonsson, Michael; Gregorič Kramberger, Milica; Lossi, Laura; Malojčić, Branko; Mehrabian, Shima; Merighi, Adalberto; Mukaetova-Ladinska, Elizabeta Blagoja; Paraskevas, George P.; Popescu, Bogdan Ovidiu; Ravid, Rivka; Traykov, Latchezar; Tsivgoulis, Georgios; Weinstein, Galit; Korczyn, Amos; Bjerke, Maria; Rosenberg, Gary Više autora...

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Wallin, A., Kapaki, E., Boban, M., Engelborghs, S., Hermann, D. M., Huisa, B. ... Rosenberg, G. (2017). Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report. BMC Neurology, 17., 102. doi: 10.1186/s12883-017-0877-3

Wallin, Anders, et al. "Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report." BMC Neurology, vol. 17, 2017, str. 102. https://doi.org/10.1186/s12883-017-0877-3

Wallin, Anders, Elisabeth Kapaki, Marina Boban, Sebastian Engelborghs, Dirk Matthias Hermann, Branko Huisa, Michael Jonsson, et al. "Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report." BMC Neurology 17 (2017): 102. https://doi.org/10.1186/s12883-017-0877-3

Wallin, A., et al. (2017) 'Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report', BMC Neurology, 17, str. 102. doi: 10.1186/s12883-017-0877-3

Wallin A, Kapaki E, Boban M, Engelborghs S, Hermann DM, Huisa B, i sur.. Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report. BMC Neurology [Internet]. 23.05.2017. [pristupljeno 13.11.2024.];17:102. doi: 10.1186/s12883-017-0877-3

A. Wallin, et al., "Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report", BMC Neurology, vol. 17, str. 102, Svibanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:605032. [Citirano: 13.11.2024.]

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Naslov (engleski)Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report
AutorAnders Wallin
AutorElisabeth Kapaki
AutorMarina Boban
AutorSebastian Engelborghs
AutorDirk Matthias Hermann
AutorBranko Huisa
AutorMichael Jonsson
AutorMilica Gregorič Kramberger
AutorLaura Lossi
AutorBranko Malojčić
AutorShima Mehrabian
AutorAdalberto Merighi
AutorElizabeta Blagoja Mukaetova-Ladinska
AutorGeorge P. Paraskevas
AutorBogdan Ovidiu Popescu
AutorRivka Ravid
AutorLatchezar Traykov
AutorGeorgios Tsivgoulis
AutorGalit Weinstein
AutorAmos Korczyn
AutorMaria Bjerke
AutorGary Rosenberg
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emerging as a major homogeneous subtype. Its progressive course raises the need for biomarker identification and/or development for adequate therapeutic interventions to be tested. In order to shed light in the current status on biochemical markers for VCI-SSVD, experts in field reviewed the recent evidence and literature data. ----- METHOD: The group conducted a comprehensive search on Medline, PubMed and Embase databases for studies published until 15.01.2017. The proposal on current status of biochemical markers in VCI-SSVD was reviewed by all co-authors and the draft was repeatedly circulated and discussed before it was finalized. ----- RESULTS: This review identifies a large number of biochemical markers derived from CSF and blood. There is a considerable overlap of VCI-SSVD clinical symptoms with those of Alzheimer's disease (AD). Although most of the published studies are small and their findings remain to be replicated in larger cohorts, several biomarkers have shown promise in separating VCI-SSVD from AD. These promising biomarkers are closely linked to underlying SSVD pathophysiology, namely disruption of blood-CSF and blood-brain barriers (BCB-BBB) and breakdown of white matter myelinated fibres and extracellular matrix, as well as blood and brain inflammation. The leading biomarker candidates are: elevated CSF/blood albumin ratio, which reflects BCB/BBB disruption; altered CSF matrix metalloproteinases, reflecting extracellular matrix breakdown; CSF neurofilment as a marker of axonal damage, and possibly blood inflammatory cytokines and adhesion molecules. The suggested SSVD biomarker deviations contrasts the characteristic CSF profile in AD, i.e. depletion of amyloid beta peptide and increased phosphorylated and total tau. ----- CONCLUSIONS: Combining SSVD and AD biomarkers may provide a powerful tool to identify with greater precision appropriate patients for clinical trials of more homogeneous dementia populations. Thereby, biomarkers might promote therapeutic progress not only in VCI-SSVD, but also in AD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBMC Neurology
Brojčani podacivol. 17, str. 102
p-ISSN1471-2377
DOIhttps://doi.org/10.1186/s12883-017-0877-3
URN:NBNurn:nbn:hr:105:605032
Datum objave publikacije2017-05-23
URL dokumentahttps://doi.org/10.1186/s12883-017-0877-3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:12:42