prikaz prve stranice dokumenta Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
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Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
Journal of Global Antimicrobial Resistance, 10 (2017); 213-218. https://doi.org/10.1016/j.jgar.2017.07.001
Ladavac, Ranko; Bedenić, Branka; Vranić-Ladavac, Mirna; Barišić, Nada; Karčić, Natalie; Pompe, Karoline; Ferenčić, Antun; Stojanović, Aleksandar; Seifert, Harald; Katić, Stjepan; Higgins, Paul G.

Citirajte ovaj rad

Ladavac, R., Bedenić, B., Vranić Ladavac, M., Barišić, N., Karčić, N., Pompe, K. ... Higgins, P. G. (2017). Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility. Journal of Global Antimicrobial Resistance, 10., 213-218. doi: 10.1016/j.jgar.2017.07.001

Ladavac, Ranko, et al. "Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility." Journal of Global Antimicrobial Resistance, vol. 10, 2017, str. 213-218. https://doi.org/10.1016/j.jgar.2017.07.001

Ladavac, Ranko, Branka Bedenić, Mirna Vranić Ladavac, Nada Barišić, Natalie Karčić, Karoline Pompe, Antun Ferenčić, et al. "Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility." Journal of Global Antimicrobial Resistance 10 (2017): 213-218. https://doi.org/10.1016/j.jgar.2017.07.001

Ladavac, R., et al. (2017) 'Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility', Journal of Global Antimicrobial Resistance, 10, str. 213-218. doi: 10.1016/j.jgar.2017.07.001

Ladavac R, Bedenić B, Vranić Ladavac M, Barišić N, Karčić N, Pompe K, i sur.. Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility. Journal of Global Antimicrobial Resistance [Internet]. 09.2017. [pristupljeno 15.04.2024.];10:213-218. doi: 10.1016/j.jgar.2017.07.001

R. Ladavac, et al., "Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility", Journal of Global Antimicrobial Resistance, vol. 10, str. 213-218, Rujan 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:282074. [Citirano: 15.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:282074
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Podaci o radu
Naslov (engleski)Emergence of different Acinetobacter baumannii clones in a Croatian hospital and correlation with antibiotic susceptibility
AutorRanko Ladavac
AutorBranka Bedenić
AutorMirna Vranić-Ladavac
AutorNada Barišić
AutorNatalie Karčić
AutorKaroline Pompe
AutorAntun Ferenčić
AutorAleksandar Stojanović
AutorHarald Seifert
AutorStjepan Katić
AutorPaul G. Higgins
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES: During routine diagnostic laboratory work, the clinical microbiologist observed an increase of Acinetobacter baumannii isolates with three different carbapenem susceptibility patterns: susceptible, intermediate and resistant. Isolates belonging to the same carbapenem susceptibility phenotype exhibited identical susceptibility/resistance patterns to non-β-lactam antibiotics. This prompted us to analyse the mechanisms of carbapenem-resistance and the molecular epidemiology of the isolates. A total of 59 A. baumannii isolates were analysed and grouped according to their susceptibility to imipenem: group 1 were susceptible (N=24), group 2 were intermediate (N=8) and group 3 were resistant (N=27) to imipenem. ----- MATERIAL AND METHODS: PCR and sequencing was used to detect resistance genes. Genotyping of the isolates was performed by PFGE and MLST. ----- RESULTS: Out of 27 resistant isolates, 20 harboured blaOXA-40-like and 7 blaOXA-23-like genes. ISAba1 was found upstream of blaOXA-51 and blaOXA-23 genes. PFGE genotyping demonstrated the existence of three major A. baumannii clones in GH Pula and determination of sequence groups showed that the isolates belonged to international clones commonly associated with multidrug-resistance. MLST (performed on six isolates) showed diverse population structure of isolates belonging to the same cluster, including ST 195, ST 231, ST 775 and ST 1095. ----- CONCLUSIONS: A previous study conducted in 2009-2010 showed that reduced susceptibility to carbapenems in GH Pula was only associated with upregulation of the intrinsic OXA-51 β-lactamase. In this study a shift to isolates with acquired oxacillinases, belonging to two major clones was reported.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Global Antimicrobial Resistance
Brojčani podacivol. 10, str. 213-218
p-ISSN2213-7165
DOIhttps://doi.org/10.1016/j.jgar.2017.07.001
URN:NBNurn:nbn:hr:105:282074
Datum objave publikacije2017-09
URL dokumentahttps://doi.org/10.1016/j.jgar.2017.07.001
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:14:04