prikaz prve stranice dokumenta Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retros
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Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study
Frontiers in Psychiatry, 8 (2017); 277. https://doi.org/10.3389/fpsyt.2017.00277
Henigsberg, Neven; Šarac, Helena; Radoš, Marko; Radoš, Milan; Ozretić, David; Foro, Tamara; Erdeljić Turk, Viktorija; Hrabač, Pero; Bajs Janović, Maja; Rak, Benedict; Kalember, Petra

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Henigsberg, N., Šarac, H., Radoš, M., Radoš, M., Ozretić, D., Foro, T. ... Kalember, P. (2017). Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study. Frontiers in Psychiatry, 8., 277. doi: 10.3389/fpsyt.2017.00277

Henigsberg, Neven, et al. "Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study." Frontiers in Psychiatry, vol. 8, 2017, str. 277. https://doi.org/10.3389/fpsyt.2017.00277

Henigsberg, Neven, Helena Šarac, Marko Radoš, Milan Radoš, David Ozretić, Tamara Foro, Viktorija Erdeljić Turk, et al. "Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study." Frontiers in Psychiatry 8 (2017): 277. https://doi.org/10.3389/fpsyt.2017.00277

Henigsberg, N., et al. (2017) 'Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study', Frontiers in Psychiatry, 8, str. 277. doi: 10.3389/fpsyt.2017.00277

Henigsberg N, Šarac H, Radoš M, Radoš M, Ozretić D, Foro T, i sur.. Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study. Frontiers in Psychiatry [Internet]. 13.12.2017. [pristupljeno 27.04.2024.];8:277. doi: 10.3389/fpsyt.2017.00277

N. Henigsberg, et al., "Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study", Frontiers in Psychiatry, vol. 8, str. 277, Prosinac 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:027703. [Citirano: 27.04.2024.]

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Naslov (engleski)Lower choline-containing metabolites/creatine (Cr) rise and failure to sustain NAA/Cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study
AutorNeven Henigsberg
AutorHelena Šarac
AutorMarko Radoš
AutorMilan Radoš
AutorDavid Ozretić
AutorTamara Foro
AutorViktorija Erdeljić Turk
AutorPero Hrabač
AutorMaja Bajs Janović
AutorBenedict Rak
AutorPetra Kalember
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: The aim of this study was to evaluate the relationship between changes in proton magnetic resonance spectroscopy (1H-MRS) parameters at the start of the index episode recovery phase and at recurrence in patients with recurrent depression who were treated with prolonged maintenance therapy. ----- Methods: 1H-MRS parameters were analyzed in 48 patients with recurrent depression who required maintenance therapy with antidepressant medication prescribed by a psychiatrist and who continued with the same antidepressant during the maintenance phase, either to recurrence of depression, completion of the 10-year observation period, or the start of the withdrawal phase (tapering-off antidepressant). N-acetylaspartate (NAA), choline-containing metabolites (Cho), creatine (Cr), and glutamine/glutamate were measured at the start of the recovery phase and 6 months later. ----- Results: Recurrent depressive episodes occurred in 20 patients. These individuals had a smaller increase in Cho/Cr after the beginning of the recovery phase compared to the non-recurrent patient group and also exhibited a decreased NAA/Cr ratio. ----- Conclusion: Sustainable NAA and increased Cho levels at the onset of the recovery phase of the index episode are early markers of antidepressant effectiveness associated with a lower risk of major depressive disorder recurrence. The NAA and Cho changes in the non-recurrent group may be attributable to increased brain resilience, contrary to the transient temporal effect observed in subjects who experienced a depressive episode.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Psychiatry
Brojčani podacivol. 8, str. 277
p-ISSN1664-0640
DOIhttps://doi.org/10.3389/fpsyt.2017.00277
URN:NBNurn:nbn:hr:105:027703
Datum objave publikacije2017-12-13
URL dokumentahttp://doi.org/10.3389/fpsyt.2017.00277
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:21:15