prikaz prve stranice dokumenta HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse
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HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse
Human Immunology, 78 (2017), 11-12; 665-671. https://doi.org/10.1016/j.humimm.2017.08.008
Burek Kamenarić, Marija; Maskalan, Marija; Grubić, Zorana; Mikulić, Mirta; Serventi Seiwerth, Ranka; Duraković, Nadira; Vrhovac, Radovan; Štingl Janković, Katarina; Žunec, Renata

Citirajte ovaj rad

Burek Kamenarić, M., Maskalan, M., Grubić, Z., Mikulić, M., Serventi Seiwerth, R., Duraković, N. ... Žunec, R. (2017). HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse. Human Immunology, 78. (11-12), 665-671. doi: 10.1016/j.humimm.2017.08.008

Burek Kamenarić, Marija, et al. "HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse." Human Immunology, vol. 78, br. 11-12, 2017, str. 665-671. https://doi.org/10.1016/j.humimm.2017.08.008

Burek Kamenarić, Marija, Marija Maskalan, Zorana Grubić, Mirta Mikulić, Ranka Serventi Seiwerth, Nadira Duraković, Radovan Vrhovac, Katarina Štingl Janković i Renata Žunec. "HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse." Human Immunology 78, br. 11-12 (2017): 665-671. https://doi.org/10.1016/j.humimm.2017.08.008

Burek Kamenarić, M., et al. (2017) 'HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse', Human Immunology, 78(11-12), str. 665-671. doi: 10.1016/j.humimm.2017.08.008

Burek Kamenarić M, Maskalan M, Grubić Z, Mikulić M, Serventi Seiwerth R, Duraković N, i sur.. HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse. Human Immunology [Internet]. 11.2017. [pristupljeno 31.12.2024.];78(11-12):665-671. doi: 10.1016/j.humimm.2017.08.008

M. Burek Kamenarić, et al., "HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse", Human Immunology, vol. 78, br. 11-12, str. 665-671, Studeni 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:006478. [Citirano: 31.12.2024.]

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Podaci o radu
Naslov (engleski)HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse
AutorMarija Burek Kamenarić
AutorMarija Maskalan
AutorZorana Grubić
AutorMirta Mikulić
AutorRanka Serventi Seiwerth
AutorNadira Duraković
AutorRadovan Vrhovac
AutorKatarina Štingl Janković
AutorRenata Žunec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The impact of patient/donor matching for HLA-A, -B, -C, -DRB1 and -DQB1 genes in hematopoietic stem cell transplantation (HSCT) is well-recognized, but typing for additional genes, such as HLA-DPB1, is still controversial. Based on defined T-cell epitope (TCE) groups, all HLA-DPB1 mismatches can be classified as permissive or non-permissive. In this retrospective study we analysed 82 patient-matched unrelated donor (MUD) pairs who underwent HSCT, and explored the impact of HLA-DPB1 matches, permissive and non-permissive mismatches on transplantation outcomes. Patient-MUD pairs matched for HLA-DPB1 alleles in univariate analysis were associated with a significantly higher incidence of disease relapse compared to pairs who were permissive/non-permissive HLA-DPB1 mismatched according to the TCE3 and TCE4 algorithms (P=0.025 and P=0.026, respectively), although the significance was lost in multivariate analysis. The analysis did not reveal any significant influence of HLA-DPB1 alleles on overall survival (OS), non-relapse mortality (NRM) or graft-versus-host disease (GvHD) incidence. In conclusion, our study presents evidence that HLA-DPB1 matching influenced the relapse rate in patients after HSCT so the HLA-DPB1 alleles should be implemented in the MUD search algorithm as a transplantation determinant.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaHuman Immunology
Brojčani podacivol. 78, br. 11-12, str. 665-671
p-ISSN0198-8859
DOIhttps://doi.org/10.1016/j.humimm.2017.08.008
URN:NBNurn:nbn:hr:105:006478
Datum objave publikacije2017-11
URL dokumentahttps://doi.org/10.1016/j.humimm.2017.08.008
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:22:42