prikaz prve stranice dokumenta Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential
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Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential
Clinical Oral Investigations, 22 (2018), 2; 1071-1082. https://doi.org/10.1007/s00784-017-2190-3
Lončar-Brzak, Božana; Klobučar, Marko; Veliki-Dalić, Irena; Sabol, Ivan; Kraljević Pavelić, Sandra; Krušlin, Božo; Mravak-Stipetić, Marinka

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Lončar Brzak, B., Klobučar, M., Veliki Dalić, I., Sabol, I., Kraljević Pavelić, S., Krušlin, B. i Mravak Stipetić, M. (2018). Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential. Clinical Oral Investigations, 22. (2), 1071-1082. doi: 10.1007/s00784-017-2190-3

Lončar Brzak, Božana, et al. "Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential." Clinical Oral Investigations, vol. 22, br. 2, 2018, str. 1071-1082. https://doi.org/10.1007/s00784-017-2190-3

Lončar Brzak, Božana, Marko Klobučar, Irena Veliki Dalić, Ivan Sabol, Sandra Kraljević Pavelić, Božo Krušlin i Marinka Mravak Stipetić. "Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential." Clinical Oral Investigations 22, br. 2 (2018): 1071-1082. https://doi.org/10.1007/s00784-017-2190-3

Lončar Brzak, B., et al. (2018) 'Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential', Clinical Oral Investigations, 22(2), str. 1071-1082. doi: 10.1007/s00784-017-2190-3

Lončar Brzak B, Klobučar M, Veliki Dalić I, Sabol I, Kraljević Pavelić S, Krušlin B, i sur.. Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential. Clinical Oral Investigations [Internet]. 03.2018. [pristupljeno 02.05.2024.];22(2):1071-1082. doi: 10.1007/s00784-017-2190-3

B. Lončar Brzak, et al., "Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential", Clinical Oral Investigations, vol. 22, br. 2, str. 1071-1082, Ožujak 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:615495. [Citirano: 02.05.2024.]

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Naslov (engleski)Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential
AutorBožana Lončar-Brzak
AutorMarko Klobučar
AutorIrena Veliki-Dalić
AutorIvan Sabol
AutorSandra Kraljević Pavelić
AutorBožo Krušlin
AutorMarinka Mravak-Stipetić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVES: The aim of this study was to examine molecular alterations on the protein level in lesions of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa. ----- MATERIALS AND METHODS: Global protein profiling methods based on liquid chromatography coupled to mass spectrometry (LC-MS) were used, with a special emphasis on evaluation of deregulated extracellular matrix molecules expression, as well as on analyses of IG2F and IGFR2 expression in healthy mucosa, OLP and OSCC tissues by comparative semi-quantitative immunohistochemistry. ----- RESULTS: Mass spectrometry-based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and accompanied histologically unaltered tissues, respectively) identified 55 extracellular matrix proteins. Twenty among identified proteins were common to all groups of samples. Expression of small leucine-rich extracellular matrix proteoglycans lumican and biglycan was found both in OSCC and OLP and they were validated by Western blot analysis as putative biomarkers. A significant increase (p < 0.05) of biglycan expression in OLP-AT group was determined in comparison with OLP-T group, while lumican showed significant up-regulation (p < 0.05) in OLP-T and OSCC-T groups vs. adjacent and control tissue groups. Biglycan expression was only determined in OSCC-AT group. Immunohistochemical analysis of IGF2 and IG2FR expression revealed no significant difference among groups of samples. ----- CONCLUSION/CLINICAL RELEVANCE: Biglycan and lumican were identified as important pathogenesis biomarkers of OLP that point to its malignant potential.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaClinical Oral Investigations
Brojčani podacivol. 22, br. 2, str. 1071-1082
p-ISSN1432-6981
DOIhttps://doi.org/10.1007/s00784-017-2190-3
URN:NBNurn:nbn:hr:105:615495
Datum objave publikacije2018-03
URL dokumentahttps://doi.org/10.1007/s00784-017-2190-3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:24:04