prikaz prve stranice dokumenta Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry
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Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry
International Orthopaedics, 31 (2007), 6; 743-751. https://doi.org/10.1007/s00264-007-0404-z
Grgurević, Lovorka; Maček, Boris; Đurđević, Dragan; Vukičević, Slobodan

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Grgurević, L., Maček, B., Đurđević, D. i Vukičević, S. (2007). Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry. International Orthopaedics, 31. (6), 743-751. doi: 10.1007/s00264-007-0404-z

Grgurević, Lovorka, et al. "Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry." International Orthopaedics, vol. 31, br. 6, 2007, str. 743-751. https://doi.org/10.1007/s00264-007-0404-z

Grgurević, Lovorka, Boris Maček, Dragan Đurđević i Slobodan Vukičević. "Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry." International Orthopaedics 31, br. 6 (2007): 743-751. https://doi.org/10.1007/s00264-007-0404-z

Grgurević, L., et al. (2007) 'Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry', International Orthopaedics, 31(6), str. 743-751. doi: 10.1007/s00264-007-0404-z

Grgurević L, Maček B, Đurđević D, Vukičević S. Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry. International Orthopaedics [Internet]. 12.2007. [pristupljeno 15.11.2024.];31(6):743-751. doi: 10.1007/s00264-007-0404-z

L. Grgurević, B. Maček, D. Đurđević i S. Vukičević, "Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry", International Orthopaedics, vol. 31, br. 6, str. 743-751, Prosinac 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:690826. [Citirano: 15.11.2024.]

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Podaci o radu
Naslov (engleski)Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry
AutorLovorka Grgurević
AutorBoris Maček
AutorDragan Đurđević
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Following bone fracture, a large number of growth factors, cytokines, and their cognate receptors involved in the repair process are active at the fracture site. To determine whether they appear in patients' blood as candidate biomarkers for following the outcome of healing, we analysed the plasma of 25 patients with an acute bone fracture following affinity plasma purification, SDS gel electrophoresis and liquid chromatography - tandem mass spectrometry (LC-MS/MS). Two hundred and thirteen nonredundant proteins were identified in the in-gel analysis of pooled plasma proteins. Gene ontology (GO) analysis indicated that a majority of detected proteins were of extracellular origin, whereas only a small number were of intracellular (cytosol and nucleus) origin. A significant proportion of detected proteins was involved in the cell growth and proliferation, transport and coagulation. Twelve proteins were potentially related to bone and cartilage metabolism, and several have not been previously identified in the plasma, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Orthopaedics
Brojčani podacivol. 31, br. 6, str. 743-751
p-ISSN0341-2695
DOIhttps://doi.org/10.1007/s00264-007-0404-z
URN:NBNurn:nbn:hr:105:690826
Datum objave publikacije2007-12
URL dokumentahttps://doi.org/10.1007/s00264-007-0404-z
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:26:06