prikaz prve stranice dokumenta Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective
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Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study
Croatian Medical Journal, 59 (2018), 5; 244-252. https://doi.org/10.3325/cmj.2018.59.244
Henigsberg, Neven; Savić, Aleksandar; Radoš, Marko; Šarac, Helena; Radoš, Milan; Ozretić, David; Bajs Janović, Maja; Erdeljić Turk, Viktorija; Šečić, Ana; Kalember, Petra; Hrabač, Pero

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Henigsberg, N., Savić, A., Radoš, M., Šarac, H., Radoš, M., Ozretić, D. ... Hrabač, P. (2018). Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study. Croatian Medical Journal, 59. (5), 244-252. doi: 10.3325/cmj.2018.59.244

Henigsberg, Neven, et al. "Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study." Croatian Medical Journal, vol. 59, br. 5, 2018, str. 244-252. https://doi.org/10.3325/cmj.2018.59.244

Henigsberg, Neven, Aleksandar Savić, Marko Radoš, Helena Šarac, Milan Radoš, David Ozretić, Maja Bajs Janović, et al. "Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study." Croatian Medical Journal 59, br. 5 (2018): 244-252. https://doi.org/10.3325/cmj.2018.59.244

Henigsberg, N., et al. (2018) 'Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study', Croatian Medical Journal, 59(5), str. 244-252. doi: 10.3325/cmj.2018.59.244

Henigsberg N, Savić A, Radoš M, Šarac H, Radoš M, Ozretić D, i sur.. Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study. Croatian Medical Journal [Internet]. 31.10.2018. [pristupljeno 10.04.2024.];59(5):244-252. doi: 10.3325/cmj.2018.59.244

N. Henigsberg, et al., "Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study", Croatian Medical Journal, vol. 59, br. 5, str. 244-252, Listopad 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:680821. [Citirano: 10.04.2024.]

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Podaci o radu
Naslov (engleski)Choline and N-acetyl aspartate levels in the dorsolateral prefrontal cortex at the beginning of the recovery phase as markers of increased risk for depressive episode recurrence under different duration of maintenance therapy and after it: a retrospective cohort study
AutorNeven Henigsberg
AutorAleksandar Savić
AutorMarko Radoš
AutorHelena Šarac
AutorMilan Radoš
AutorDavid Ozretić
AutorMaja Bajs Janović
AutorViktorija Erdeljić Turk
AutorAna Šečić
AutorPetra Kalember
AutorPero Hrabač
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim: To evaluate the relationship between the dynamics of proton magnetic resonance spectroscopy (1H-MRS) brain metabolite levels at the beginning of the recovery phase of the index depressive episode and the time to the recurrence of depression. Methods: This retrospective cohort study analyzed the changes in N-acetyl aspartate (NAA), choline (Cho), and glutamate-glutamine in 48 patients with recurrent depression treated with maintenance antidepressant monotherapy at a stable dose. 1H-MRS was performed at the start of the recovery phase and 6 months later. 1H-MRS parameters, index episode descriptors, and depressive disorder course were analyzed by Cox proportional hazards model. Results: NAA and Cho decrease six months after the beginning of the recovery period were time-independent risk factors for depressive episode recurrence. Hazard ratio associated with NAA decrease was 2.02 (95% confidence interval 1.06-3.84) and that associated with Cho decrease was 2.06 (95% confidence interval 1.02-4.17). These changes were not related to symptoms severity, as Montgomery-Asberg Depression Scale score remained generally unchanged (mean -0.01; standard deviation 1.6) over the first 6 months of recovery. Conclusion: Patients receiving maintenance antidepressant therapy after recovery who experience a decrease in NAA or Cho levels early in the recovery phase have a double risk of depressive episode recurrence. Sustained NAA and Cho levels at the beginning of the recovery phase may indicate increased brain resilience conferred by antidepressant therapy, while NAA and Cho decrease may indicate only the trait-related temporal effect of therapy in another stratum of patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 59, br. 5, str. 244-252
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2018.59.244
URN:NBNurn:nbn:hr:105:680821
Datum objave publikacije2018-10-31
URL dokumentahttps://doi.org/10.3325/cmj.2018.59.244
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:49:04