prikaz prve stranice dokumenta Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study
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Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study
Croatian Medical Journal, 59 (2018), 5; 232-243. https://doi.org/doi:10.3325/cmj.2018.59.232
Ravić, Katja Grubelic; Paić, Frane; Vucelić, Boris; Brinar, Marko; Čuković-Čavka, Silvija; Božina, Nada; Krznarić, Željko; Kalauz, Mirjana; Bešić, Dino; Martić, Tamara Nikuševa

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Ravić, K. G., Paić, F., Vucelić, B., Brinar, M., Čuković Čavka, S., Božina, N. ... Martić, T. N. (2018). Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study. Croatian Medical Journal, 59. (5), 232-243. doi: doi:10.3325/cmj.2018.59.232

Ravić, Katja Grubelic, et al. "Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study." Croatian Medical Journal, vol. 59, br. 5, 2018, str. 232-243. https://doi.org/doi:10.3325/cmj.2018.59.232

Ravić, Katja Grubelic, Frane Paić, Boris Vucelić, Marko Brinar, Silvija Čuković Čavka, Nada Božina, Željko Krznarić, Mirjana Kalauz, Dino Bešić i Tamara Nikuševa Martić. "Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study." Croatian Medical Journal 59, br. 5 (2018): 232-243. https://doi.org/doi:10.3325/cmj.2018.59.232

Ravić, K. G., et al. (2018) 'Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study', Croatian Medical Journal, 59(5), str. 232-243. doi: doi:10.3325/cmj.2018.59.232

Ravić KG, Paić F, Vucelić B, Brinar M, Čuković Čavka S, Božina N, i sur.. Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study. Croatian Medical Journal [Internet]. 31.10.2018. [pristupljeno 14.04.2024.];59(5):232-243. doi: doi:10.3325/cmj.2018.59.232

K. G. Ravić, et al., "Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study", Croatian Medical Journal, vol. 59, br. 5, str. 232-243, Listopad 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:059274. [Citirano: 14.04.2024.]

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Podaci o radu
Naslov (engleski)Association of polymorphic variants in serotonin re-uptake transporter gene with Crohn's disease: a retrospective case-control study
AutorKatja Grubelic Ravić
AutorFrane Paić
AutorBoris Vucelić
AutorMarko Brinar
AutorSilvija Čuković-Čavka
AutorNada Božina
AutorŽeljko Krznarić
AutorMirjana Kalauz
AutorDino Bešić
AutorTamara Nikuševa Martić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim: To analyze the distribution of SLC6A4 gene polymorphisms in Crohn's disease (CD) patients and their association with the disease. Methods: We evaluated the presence/absence of promoter (5-HTTLPR, rs25531) and intron 2 (STin2 VNTR) polymorphic variants of SLC6A4 gene in a retrospective case-control study including 192 CD patients and 157 healthy controls (HC). Genotyping was performed by polymerase chain reaction. The association of polymorphisms with CD and its clinical subtypes was analyzed using χ2 and Fisher exact test, binary logistic regression, and haplotype analysis. Results: CD patients and healthy controls had similar sex (88 [45.8%] vs 84 [53.5%] women, respectively; P=0.154) and age (41.3±12.8 years vs 41.7±8.8 years, respectively, P=0.091) distribution. Significant differences were observed in the STin2 genotype and allele distribution between CD patients and healthy controls (P=0.003 and P=0.002, respectively) and between the corresponding female subgroups (P=0.004 and P=0.007, respectively), with a significant negative association of biallelic ss (STin2.9 and Stin2.10) STin2 genotype with CD (P=0.013, age- and sex-adjusted odds ratio [OR] 0.5, 95% confidence interval [CI] 0.29-0.86; women: P=0.006, age-adjusted OR 0.32, 95% CI 0.14-0.72) and a significantly higher S-STin2.12 (5-HTTLPR/rs25531: S-STin2: STin2.12) haplotype distribution in CD patients (P=0.004, OR 1.62, 95% CI 1.16-2.26). There was no significant association between 5-HTTLRP and rs25531 genotype or allele frequencies and CD and between any SLC6A4 polymorphic loci with clinical CD subtypes. Conclusion: STin2 VNTR polymorphism of SLC6A4 gene may contribute to CD pathogenesis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 59, br. 5, str. 232-243
p-ISSN0353-9504
DOIhttps://doi.org/doi:10.3325/cmj.2018.59.232
URN:NBNurn:nbn:hr:105:059274
Datum objave publikacije2018-10-31
URL dokumentahttp://doi.org/10.3325/cmj.2018.59.232
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:50:20