prikaz prve stranice dokumenta Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study
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Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study
Journal of Neurology, 254 (2007), 12; 1676-1683. https://doi.org/10.1007/s00415-007-0611-y
Klepac, Nataša; Relja, Maja; Klepac, Ratimir; Hećimović, Silva; Babić, Tomislav; Trkulja, Vladimir

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Klepac, N., Relja, M., Klepac, R., Hećimović, S., Babić, T. i Trkulja, V. (2007). Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study. Journal of Neurology, 254. (12), 1676-1683. doi: 10.1007/s00415-007-0611-y

Klepac, Nataša, et al. "Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study." Journal of Neurology, vol. 254, br. 12, 2007, str. 1676-1683. https://doi.org/10.1007/s00415-007-0611-y

Klepac, Nataša, Maja Relja, Ratimir Klepac, Silva Hećimović, Tomislav Babić i Vladimir Trkulja. "Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study." Journal of Neurology 254, br. 12 (2007): 1676-1683. https://doi.org/10.1007/s00415-007-0611-y

Klepac, N., et al. (2007) 'Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study', Journal of Neurology, 254(12), str. 1676-1683. doi: 10.1007/s00415-007-0611-y

Klepac N, Relja M, Klepac R, Hećimović S, Babić T, Trkulja V. Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study. Journal of Neurology [Internet]. 12.2007. [pristupljeno 15.04.2024.];254(12):1676-1683. doi: 10.1007/s00415-007-0611-y

N. Klepac, M. Relja, R. Klepac, S. Hećimović, T. Babić i V. Trkulja, "Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study", Journal of Neurology, vol. 254, br. 12, str. 1676-1683, Prosinac 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:833899. [Citirano: 15.04.2024.]

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Podaci o radu
Naslov (engleski)Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study
AutorNataša Klepac
AutorMaja Relja
AutorRatimir Klepac
AutorSilva Hećimović
AutorTomislav Babić
AutorVladimir Trkulja
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND : Animal data and postmortem studies suggest a role of oxidative stress in the Huntington's disease (HD), but in vivo human studies have been scarce. ----- AIM : To assess the presence of oxidative stress in HD patients and its occurrence relative to clinical symptoms. ----- METHODS : Oxidative stress markers were determined in plasma of HD patients (n = 19), asymptomatic HD gene carriers (with > 38 CAG repeats) (n = 11) and their respective sex and agematched healthy controls (n = 47 and n = 22) in a cross-sectional study. ----- RESULTS : With adjustment for age and sex, HD patients had higher plasma lipid peroxidation (LP) levels (ratio 1.20, 95% CI 1.09 to 1.32, p < 0.001) and lower reduced glutathione (GSH) levels (ratio 0.72, CI 0.55 to 0.94, p = 0.011) than their age and sex-matched controls. Although considerably younger, HD gene carriers did not differ from HD patients regarding LP and GSH levels, and had higher plasma LP (ratio 1.16, CI 1.02 to 1.32, p = 0.016) and lower GSH than their matched controls (ratio 0.73, CI 0.5 to 1.05). They had higher LP (ratio 1.18, CI 1.02 to 1.34, p = 0.019) and lower GSH (ratio 0.75, CI 0.51 to 1.11) than the healthy subjects matched to HD patients. ----- CONCLUSIONS : Oxidative stress is more pronounced in HD patients and asymptomatic HD gene carriers than in healthy subjects. Differences in plasma LP and GSH are in line with the brain findings in animal models of HD. Data suggest that oxidative stress occurs before the onset of the HD symptoms.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Neurology
Brojčani podacivol. 254, br. 12, str. 1676-1683
p-ISSN0340-5354
DOIhttps://doi.org/10.1007/s00415-007-0611-y
URN:NBNurn:nbn:hr:105:833899
Datum objave publikacije2007-12
URL dokumentahttps://doi.org/10.1007/s00415-007-0611-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:52:52