US and MRI in the evaluation of mammographic BI-RADS 4 and 5 microcalcifications

Znanstveni rad - Izvorni znanstveni rad

• Autor: Ana Hrkac Pustahija
• Autor: Gordana Ivanac
• Autor: Boris Brkljačić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

PURPOSE:

The aim of this study was to assess diagnostic accuracies of ultrasonography (US) and magnetic resonance imaging (MRI) in lesions that manifest as mammographic BI-RADS 4 and 5 microcalcifications, in the setting of conjoined use of mammography, US, and MRI. -----

METHODS:

Patients with mammographic BI-RADS 4 or 5 microcalcifications, without additional findings, were included in this prospective study. All patients subsequently underwent breast US and MRI. Histopathologic diagnosis, obtained by US-guided core-needle biopsy or surgical excision, served as a reference standard. Diagnostic accuracies of US and MRI were calculated, and positive predictive value for different MRI BI-RADS imaging features were determined. -----

RESULTS:

The study group consisted of 113 women with 125 areas of suspicious microcalcifications. MRI reached sensitivity, specificity, positive predictive value 3 (PPV3), and negative predictive value (NPV) of 100%, 70.1%, 67.6%, and 100%, respectively. Statistically significant differences in MRI morphologic features and kinetic enhancement curves were observed between malignant and benign microcalcifications. Sensitivity, specificity, PPV3, and NPV for US were: 85.4%, 66.2%, 61.2%, and 87.9%. There was statistically significant difference in presentation of malignant and benign microcalcifications at US. -----

CONCLUSION:

In the setting of conjoined use of mammography, US, and MRI, MRI can reliably exclude malignancy in suspicious microcalcifications. Thus, negative MRI findings may influence the decision to biopsy the microcalcifications.

• Ključne riječi (engleski): Adult; Aged; Breast/diagnostic imaging; Breast/pathology; Breast Neoplasms/diagnostic imaging; Breast Neoplasms/pathology; Calcinosis/diagnostic imaging; Calcinosis/pathology; Female; Humans; Magnetic Resonance Imaging/methods; Middle Aged; Prospective Studies; Radiology Information Systems; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Ultrasonography, Mammary/methods
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Diagnostic and Interventional Radiology
• Brojčani podaci: vol. 24, br. 4, str. 187-194
• p-ISSN: 1305-3612
• DOI: https://doi.org/10.5152/dir.2018.17414
• URN:NBN: urn:nbn:hr:105:705549
• Datum objave publikacije: 2018-07
• URL dokumenta: https://doi.org/10.5152/dir.2018.17414
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 09:57:49