prikaz prve stranice dokumenta Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine
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Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine
World Journal of Gastroenterology, 24 (2018), 47; 5366-5378. https://doi.org/10.3748/wjg.v24.i47.5366
Amić, Fedor; Drmić, Domagoj; Bilić, Zdenko; Krežić, Ivan; Žizek, Helena; Peklić, Marina; Kliček, Robert; Pajtak, Alen; Amić, Enio; Vidović, Tinka; Rakić, Mislav; Milković Periša, Marija; Horvat Pavlov, Katarina; Kokot, Antonio; Tvrdeić, Ante; Boban Blagaić, Alenka; Zovak, Mario; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Amić, F., Drmić, D., Bilić, Z., Krežić, I., Žizek, H., Peklić, M. ... Sikirić, P. (2018). Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine. World Journal of Gastroenterology, 24. (47), 5366-5378. doi: 10.3748/wjg.v24.i47.5366

Amić, Fedor, et al. "Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine." World Journal of Gastroenterology, vol. 24, br. 47, 2018, str. 5366-5378. https://doi.org/10.3748/wjg.v24.i47.5366

Amić, Fedor, Domagoj Drmić, Zdenko Bilić, Ivan Krežić, Helena Žizek, Marina Peklić, Robert Kliček, et al. "Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine." World Journal of Gastroenterology 24, br. 47 (2018): 5366-5378. https://doi.org/10.3748/wjg.v24.i47.5366

Amić, F., et al. (2018) 'Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine', World Journal of Gastroenterology, 24(47), str. 5366-5378. doi: 10.3748/wjg.v24.i47.5366

Amić F, Drmić D, Bilić Z, Krežić I, Žizek H, Peklić M, i sur.. Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine. World Journal of Gastroenterology [Internet]. 21.12.2018. [pristupljeno 10.01.2025.];24(47):5366-5378. doi: 10.3748/wjg.v24.i47.5366

F. Amić, et al., "Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine", World Journal of Gastroenterology, vol. 24, br. 47, str. 5366-5378, Prosinac 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:481354. [Citirano: 10.01.2025.]

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Naslov (engleski)Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine
AutorFedor Amić
AutorDomagoj Drmić
AutorZdenko Bilić
AutorIvan Krežić
AutorHelena Žizek
AutorMarina Peklić
AutorRobert Kliček
AutorAlen Pajtak
AutorEnio Amić
AutorTinka Vidović
AutorMislav Rakić
AutorMarija Milković Periša
AutorKatarina Horvat Pavlov
AutorAntonio Kokot
AutorAnte Tvrdeić
AutorAlenka Boban Blagaić
AutorMario Zovak
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement. ----- METHODS: Male Wistar rats underwent superior anterior pancreaticoduodenal vein (SAPDV)-ligation and were treated with a bath at the ligated SAPDV site (BPC 157 10 μg, 10 ng/kg per 1 mL bath/rat; L-NAME 5 mg/kg per 1 mL bath/rat; L-arginine 100 mg/kg per 1 mL bath/rat, alone and/or together; or BPC 157 10 μg/kg instilled into the rat stomach, at 1 min ligation-time). We recorded the vessel presentation (filled/appearance or emptied/disappearance) between the 5 arcade vessels arising from the SAPDV on the ventral duodenum side, the inferior anterior pancreaticoduodenal vein (IAPDV) and superior mesenteric vein (SMV) as bypassing vascular pathway to document the duodenal lesions presentation; increased NO- and oxidative stress [malondialdehyde (MDA)]-levels in duodenum. ----- RESULTS: Unlike the severe course in the SAPDV-ligated controls, after BPC 157 application, the rats exhibited strong attenuation of the mucosal lesions and serosal congestion, improved vessel presentation, increased interconnections, increased branching by more than 60% from the initial value, the IAPDV and SMV were not congested. Interestingly, after 5 min and 30 min of L-NAME and L-arginine treatment alone, decreased mucosal and serosal duodenal lesions were observed; their effect was worsened at 24 h, and no effect on the collateral vessels and branching was seen. Together, L-NAME+L-arginine antagonized each other's response, and thus, there was an NO-related effect. With BPC 157, all SAPDV-ligated rats receiving L-NAME and/or L-arginine appeared similar to the rats treated with BPC 157 alone. Also, BPC 157 in SAPDV-ligated rats normalized levels of NO and MDA, two oxidative stress markers, in duodenal tissues. ----- CONCLUSION: BPC 157, rapidly bypassing occlusion, rescued the original duodenal flow through IAPDV to SMV flow, an effect related to the NO system and reduction of free radical formation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaWorld Journal of Gastroenterology
Brojčani podacivol. 24, br. 47, str. 5366-5378
p-ISSN1007-9327
DOIhttps://doi.org/10.3748/wjg.v24.i47.5366
URN:NBNurn:nbn:hr:105:481354
Datum objave publikacije2018-12-21
URL dokumentahttps://doi.org/10.3748/wjg.v24.i47.5366
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:00:28