prikaz prve stranice dokumenta Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder
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Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32 (2008), 2; 544-551. https://doi.org/10.1016/j.pnpbp.2007.10.014
Kovačić, Zrnka; Henigsberg, Neven; Pivac, Nela; Nedić, Gordana; Borovečki, Andrea

Citirajte ovaj rad

Kovačić, Z., Henigsberg, N., Pivac, N., Nedić, G. i Borovečki, A. (2008). Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32. (2), 544-551. doi: 10.1016/j.pnpbp.2007.10.014

Kovačić, Zrnka, et al. "Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, br. 2, 2008, str. 544-551. https://doi.org/10.1016/j.pnpbp.2007.10.014

Kovačić, Zrnka, Neven Henigsberg, Nela Pivac, Gordana Nedić i Andrea Borovečki. "Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder." Progress in Neuro-Psychopharmacology and Biological Psychiatry 32, br. 2 (2008): 544-551. https://doi.org/10.1016/j.pnpbp.2007.10.014

Kovačić, Z., et al. (2008) 'Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(2), str. 544-551. doi: 10.1016/j.pnpbp.2007.10.014

Kovačić Z, Henigsberg N, Pivac N, Nedić G, Borovečki A. Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 15.02.2008. [pristupljeno 22.12.2024.];32(2):544-551. doi: 10.1016/j.pnpbp.2007.10.014

Z. Kovačić, N. Henigsberg, N. Pivac, G. Nedić i A. Borovečki, "Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, br. 2, str. 544-551, Veljača 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:745820. [Citirano: 22.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:745820
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Podaci o radu
Naslov (engleski)Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder
AutorZrnka Kovačić
AutorNeven Henigsberg
AutorNela Pivac
AutorGordana Nedić
AutorAndrea Borovečki
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Posttraumatic stress disorder (PTSD) is a serious and global problem, a psychiatric disorder that frequently occurs with different comorbidities, and is associated with a high suicide rate. Pathophysiologically, both PTSD and suicidal behavior are related to disturbances in the central serotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) controls emotional behavior, anxiety, impulsivity and aggression, and nearly all known antidepressants and antianxiety drugs affect 5-HT transmission. Platelet 5-HT can be used as a limited peripheral marker of the central serotonergic synaptosomes, since it is related to particular basic psychopathological characteristics of several psychiatric disorders. Platelet 5-HT concentration has been reported to be similar in PTSD subjects and healthy controls, but suicidal patients across different psychiatric diagnoses have reduced platelet 5-HT concentration. This study examined platelet 5-HT concentration by the spectrofluorimetric method in male subjects: 73 suicidal and 47 non-suicidal veterans with current and chronic combat related PTSD, 45 suicidal and 30 non-suicidal comparative non-PTSD subjects and 147 healthy men. The presence of suicidal behavior (score=0, non-suicidal; scores >/=1, suicidal) was assessed with the Hamilton Depression Rating Scale-17 (HDRS). Platelet 5-HT concentration was significantly lower in suicidal PTSD and non-PTSD patients compared to non-suicidal patients or healthy controls. Since the majority of patients scored very low on item 3 of HDRS, no significant correlation between suicidal scores and platelet 5-HT concentration was found. These results show that reduced platelet 5-HT concentration is related to suicidal behavior in PTSD, and suggest that platelet 5-HT concentration might be used as a peripheral marker to predict suicidal behavior across psychiatric diagnoses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaProgress in Neuro-Psychopharmacology and Biological Psychiatry
Brojčani podacivol. 32, br. 2, str. 544-551
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2007.10.014
URN:NBNurn:nbn:hr:105:745820
Datum objave publikacije2008-02-15
URL dokumentahttps://doi.org/10.1016/j.pnpbp.2007.10.014
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:59:55