prikaz prve stranice dokumenta Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
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Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
Translational Psychiatry, 8 (2018), 1; 150. https://doi.org/doi:10.1038/s41398-018-0198-3
Ren, Hongyan; Fabbri, Chiara; Uher, Rudolf; Rietschel, Marcella; Mors, Ole; Henigsberg, Neven; Hauser, Joanna; Zobel, Astrid; Maier, Wolfgang; Dernovsek, Mojca Z.; Souery, Daniel; Cattaneo, Annamaria; Breen, Gerome; Craig, Ian W.; Farmer, Anne E.; McGuffin, Peter; Lewis, Cathryn M.; Aitchison, Katherine J. Više autora...

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Ren, H., Fabbri, C., Uher, R., Rietschel, M., Mors, O., Henigsberg, N. ... Aitchison, K. J. (2018). Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP). Translational Psychiatry, 8. (1), 150. doi: doi:10.1038/s41398-018-0198-3

Ren, Hongyan, et al. "Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)." Translational Psychiatry, vol. 8, br. 1, 2018, str. 150. https://doi.org/doi:10.1038/s41398-018-0198-3

Ren, Hongyan, Chiara Fabbri, Rudolf Uher, Marcella Rietschel, Ole Mors, Neven Henigsberg, Joanna Hauser, et al. "Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)." Translational Psychiatry 8, br. 1 (2018): 150. https://doi.org/doi:10.1038/s41398-018-0198-3

Ren, H., et al. (2018) 'Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)', Translational Psychiatry, 8(1), str. 150. doi: doi:10.1038/s41398-018-0198-3

Ren H, Fabbri C, Uher R, Rietschel M, Mors O, Henigsberg N, i sur.. Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP). Translational Psychiatry [Internet]. 13.08.2018. [pristupljeno 28.04.2024.];8(1):150. doi: doi:10.1038/s41398-018-0198-3

H. Ren, et al., "Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)", Translational Psychiatry, vol. 8, br. 1, str. 150, Kolovoz 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:522445. [Citirano: 28.04.2024.]

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Naslov (engleski)Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
AutorHongyan Ren
AutorChiara Fabbri
AutorRudolf Uher
AutorMarcella Rietschel
AutorOle Mors
AutorNeven Henigsberg
AutorJoanna Hauser
AutorAstrid Zobel
AutorWolfgang Maier
AutorMojca Z. Dernovsek
AutorDaniel Souery
AutorAnnamaria Cattaneo
AutorGerome Breen
AutorIan W. Craig
AutorAnne E. Farmer
AutorPeter McGuffin
AutorCathryn M. Lewis
AutorKatherine J. Aitchison
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide association study (GWAS) followed by investigation of biological pathway enrichment using an anhedonia dimension for 759 patients with MDD in the GENDEP study. The GWAS identified 18 SNPs associated at genome-wide significance with the top one being an intronic SNP (rs9392549) in PRPF4B (pre-mRNA processing factor 4B) located on chromosome 6 (P = 2.07 × 10-9) while gene-set enrichment analysis returned one gene ontology term, axon cargo transport (GO: 0008088) with a nominally significant P value (1.15 × 10-5). Furthermore, our exploratory analysis yielded some interesting, albeit not statistically significant genetic correlation with Parkinson's Disease and nucleus accumbens gray matter. In addition, polygenic risk scores (PRSs) generated from our association analysis were found to be able to predict treatment efficacy of the antidepressants in this study. In conclusion, we found some markers significantly associated with anhedonia, and some suggestive findings of related pathways and biological functions, which could be further investigated in other studies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaTranslational Psychiatry
Brojčani podacivol. 8, br. 1, str. 150
p-ISSN2158-3188
DOIhttps://doi.org/doi:10.1038/s41398-018-0198-3
URN:NBNurn:nbn:hr:105:522445
Datum objave publikacije2018-08-13
URL dokumentahttp://doi.org/10.1038/s41398-018-0198-3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:01:18