Overnight video-polysomnographic studies in children with Intractable epileptic encephalopathies

Znanstveni rad - Izvorni znanstveni rad

• Autor: Nataša Nenadić-Baranašić
• Autor: Romana Gjergja-Juraski
• Autor: Ivan Lehman
• Autor: Mirjana Turkalj
• Autor: Boro Nogalo
• Autor: Nina Barišić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

BACKGROUND The aim of this study was to assess sleep architecture and respiration during sleep in children with intractable epileptic encephalopathies using overnight video-polysomnography (V-PSG). ----- MATERIAL AND METHODS Between 2015 to 2017 overnight V-PSG recordings were made for 31 children (22 boys and 9 girls) with intractable epileptic encephalopathy with a mean age of 6.78±3.61 years and a mean body mass index (BMI) of 15.83±3.16 kg/m3. Thirty-one healthy children were matched for sex, age, and BMI as the control group. The phases of sleep studied included rapid eye movement (REM) sleep, and non-REM (NREM) phases NREM 1, NREM 2, and NREM 3. Respiratory function during sleep was evaluated. ----- RESULTS Children with epileptic encephalopathies receiving antiepileptic treatment had significantly decreased total sleep time (TST) (p=0.038), significantly increased percentage of NREM1 (p=0.033), and a significantly lower percentage of total REM (p<0.0001), compared with the control group. All children 31/31 (100%) with epileptic encephalopathies had interictal epileptiform discharges, and 4/31 (12.9%) had ictal events. The number of respiratory events did not differ significantly between the two groups (p=0.118), but children in the epileptic encephalopathy group had a significantly shorter average duration (p=0.008) and longest duration (p=0.048) of respiratory events. Average (p=0.006) and least (p=0.0004) oxygen saturation (SatO2) were significantly lower in children with epileptic encephalopathies compared with the control group. ----- CONCLUSIONS Children with epileptic encephalopathies had altered sleep architecture and marked oxygen desaturation, which supports the need for referral of children with epileptic encephalopathy for overnight sleep evaluation.

• Ključne riječi (engleski): Child; Child, Preschool; Electroencephalography/methods; Female; Humans; Male; Polysomnography/methods; Respiration; Respiratory Function Tests/methods; Sleep; Sleep Apnea, Obstructive/physiopathology; Sleep Wake Disorders/diagnostic imaging; Sleep Wake Disorders/physiopathology; Sleep, REM; Spasms, Infantile/complications
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Medical Science Monitor
• Brojčani podaci: vol. 24, str. 5405-5411
• p-ISSN: 1643-3750
• DOI: https://doi.org/doi:10.12659/MSM.908911
• URN:NBN: urn:nbn:hr:105:164047
• Datum objave publikacije: 2018-08-04
• URL dokumenta: http://doi.org/10.12659/MSM.908911
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 10:01:40