prikaz prve stranice dokumenta The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
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The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
Scientific Reports, 8 (2018), 1; 17873. https://doi.org/doi:10.1038/s41598-018-35903-5
Podrimaj-Bytyqi, Arjeta; Borovečki, Ana; Selimi, Qerim; Manxhuka-Kerliu, Suzana; Gashi, Goneta; Elezaj, Isa R.

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Podrimaj Bytyqi, A., Borovečki, A., Selimi, Q., Manxhuka Kerliu, S., Gashi, G. i Elezaj, I. R. (2018). The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma. Scientific Reports, 8. (1), 17873. doi: doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi, Arjeta, et al. "The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma." Scientific Reports, vol. 8, br. 1, 2018, str. 17873. https://doi.org/doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi, Arjeta, Ana Borovečki, Qerim Selimi, Suzana Manxhuka Kerliu, Goneta Gashi i Isa R. Elezaj. "The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma." Scientific Reports 8, br. 1 (2018): 17873. https://doi.org/doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi, A., et al. (2018) 'The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma', Scientific Reports, 8(1), str. 17873. doi: doi:10.1038/s41598-018-35903-5

Podrimaj Bytyqi A, Borovečki A, Selimi Q, Manxhuka Kerliu S, Gashi G, Elezaj IR. The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma. Scientific Reports [Internet]. 14.12.2018. [pristupljeno 14.04.2024.];8(1):17873. doi: doi:10.1038/s41598-018-35903-5

A. Podrimaj Bytyqi, A. Borovečki, Q. Selimi, S. Manxhuka Kerliu, G. Gashi i I. R. Elezaj, "The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma", Scientific Reports, vol. 8, br. 1, str. 17873, Prosinac 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:266621. [Citirano: 14.04.2024.]

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Naslov (engleski)The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
AutorArjeta Podrimaj-Bytyqi
AutorAna Borovečki
AutorQerim Selimi
AutorSuzana Manxhuka-Kerliu
AutorGoneta Gashi
AutorIsa R. Elezaj
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Bladder urothelial cell carcinoma (UCC) is an increasingly prevalent cancer worldwide, and thus, gaining a better understanding of its identifiable risk factors is a global priority. This study addressed this public health need with the understanding that cancer-initiating events, such as chromosome breakage, loss and rearrangement, can be reasonably used as biomarkers to evaluate an individual's cancer risk. Overall, forty bladder cancer patients and twenty controls were evaluated for genomic instability. To the best of the investigators' knowledge, this is the first study to perform micronucleus (MN) assays simultaneously in urothelial exfoliated cells (UEC), buccal exfoliated cells (BEC), and peripheral blood lymphocytes (PBL) in first-diagnosed, non-smoker bladder UCC patients. Additionally, the frequency of nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in PBL was evaluated. The MN frequencies in UEC, BEC, and PBL, as well as the frequencies of NPBs and NBUDs, were significantly higher in patients than in controls. In conclusion, MN assays, particularly in UEC, may be used to identify individuals who are at high risk of developing UCC, as single or as additional triage test to UroVysion FISH test. Our results further validate the efficacy of biomarkers, such as MN, NPBs, and NBUDs, as predictors of genomic instability.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 8, br. 1, str. 17873
p-ISSN2045-2322
DOIhttps://doi.org/doi:10.1038/s41598-018-35903-5
URN:NBNurn:nbn:hr:105:266621
Datum objave publikacije2018-12-14
URL dokumentahttp://doi.org/10.1038/s41598-018-35903-5
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:03:28