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Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina
Infection, Genetics and Evolution, 58 (2018); 192-198. https://doi.org/doi:10.1016/j.meegid.2017.12.021
Petrović, Tanja; Uzunović, Selma; Barišić, Ivan; Luxner, Josefa; Grisold, Andrea; Zarfel, Gernot; Ibrahimagić, Amir; Jakovac, Sanja; Slaćanac, Domagoj; Bedenić, Branka

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Petrović, T., Uzunović, S., Barišić, I., Luxner, J., Grisold, A., Zarfel, G. ... Bedenić, B. (2018). Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina. Infection, Genetics and Evolution, 58., 192-198. doi: doi:10.1016/j.meegid.2017.12.021

Petrović, Tanja, et al. "Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina." Infection, Genetics and Evolution, vol. 58, 2018, str. 192-198. https://doi.org/doi:10.1016/j.meegid.2017.12.021

Petrović, Tanja, Selma Uzunović, Ivan Barišić, Josefa Luxner, Andrea Grisold, Gernot Zarfel, Amir Ibrahimagić, Sanja Jakovac, Domagoj Slaćanac i Branka Bedenić. "Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina." Infection, Genetics and Evolution 58 (2018): 192-198. https://doi.org/doi:10.1016/j.meegid.2017.12.021

Petrović, T., et al. (2018) 'Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina', Infection, Genetics and Evolution, 58, str. 192-198. doi: doi:10.1016/j.meegid.2017.12.021

Petrović T, Uzunović S, Barišić I, Luxner J, Grisold A, Zarfel G, i sur.. Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina. Infection, Genetics and Evolution [Internet]. 03.2018. [pristupljeno 15.04.2024.];58:192-198. doi: doi:10.1016/j.meegid.2017.12.021

T. Petrović, et al., "Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina", Infection, Genetics and Evolution, vol. 58, str. 192-198, Ožujak 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:863301. [Citirano: 15.04.2024.]

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Naslov (engleski)Arrival of carbapenem-hydrolyzing-oxacillinases in Acinetobacter baumannii in Bosnia and Herzegovina
AutorTanja Petrović
AutorSelma Uzunović
AutorIvan Barišić
AutorJosefa Luxner
AutorAndrea Grisold
AutorGernot Zarfel
AutorAmir Ibrahimagić
AutorSanja Jakovac
AutorDomagoj Slaćanac
AutorBranka Bedenić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Multidrug-resistant Acinetobacter baumannii (MDR-AB) is an important threat for critically ill patients. It can infect the respiratory tract, blood, soft tissues, urinary tract and central nervous system. Recently, carbapenem-resistance was observed in A. baumannii clinical isolates from Bosnia and Herzegovina. This prompted us to analyze these isolates with regards to genotypic diversity, antibiotic susceptibility and occurrence of acquired carbapenem resistance genes. Twelve carbapenem-resistant isolates were collected at a University hospital during two different periods of 2011 and 2015-2016: four isolates in 2011 and eight isolates 2015-2016 and compared to determine the dynamic changes in carbapenemase resistance mechanisms and population structure. All twelve isolates were positive for intrinsic blaOXA-51-like, nine for blaOXA-40-like and one for the blaOXA-23-like gene. ISAba1 was found upstream of blaOXA-51 in all and upstream of blaOXA-23-like gene in one isolate. Sequencing of the selected PCR products revealed the presence of OXA-72 β- lactamase (strain 1) and OXA-23 β-lactamase (strain 41). WGS of the selected isolate (AB 5) revealed the presence of blaOXA-72, chromosomal genes blaOXA-69 and blaADC. Moreover, the aac (3)-1a and aadA1 genes encoding aminoglycoside resistance, and sul1encoding sulphonamide resistance were identified. PFGE and rep-PCR revealed two clones containing highly similar isolates positive for OXA-40-like; one from 2011 and the other from 2015- 2016. Implementation of hospital hygiene measures, screening of the patients on admission for carriage of MDR-AB, and the early and accurate detection, with restriction of antibiotic use should be recommended to control the spread of these important hospital pathogenes. To our knowledge, this is the first report of A. baumannii isolates producing carbapenem-hydrolyzing oxacillinases (CHDL) from Bosnia and Herzegovina.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInfection, Genetics and Evolution
Brojčani podacivol. 58, str. 192-198
p-ISSN1567-1348
DOIhttps://doi.org/doi:10.1016/j.meegid.2017.12.021
URN:NBNurn:nbn:hr:105:863301
Datum objave publikacije2018-03
URL dokumentahttp://doi.org/10.1016/j.meegid.2017.12.021
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:08:27