prikaz prve stranice dokumenta A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
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A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
Endocrine, 60 (2018), 3; 395-406. https://doi.org/10.1007/s12020-018-1592-6
Kruljac, Ivan; Vurnek, Ivan; Maasberg, Sebastian; Kust, Davor; Blaslov, Kristina; Ladika Davidović, Blaženka; Štefanović, Mario; Demirović, Alma; Bišćanin, Alen; Filipović-Čugura, Jakša; Marić Brozić, Jasmina; Pape, Ulrich-Frank; Vrkljan, Milan

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Kruljac, I., Vurnek, I., Maasberg, S., Kust, D., Blaslov, K., Ladika Davidović, B. ... Vrkljan, M. (2018). A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms. Endocrine, 60. (3), 395-406. doi: 10.1007/s12020-018-1592-6

Kruljac, Ivan, et al. "A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms." Endocrine, vol. 60, br. 3, 2018, str. 395-406. https://doi.org/10.1007/s12020-018-1592-6

Kruljac, Ivan, Ivan Vurnek, Sebastian Maasberg, Davor Kust, Kristina Blaslov, Blaženka Ladika Davidović, Mario Štefanović, et al. "A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms." Endocrine 60, br. 3 (2018): 395-406. https://doi.org/10.1007/s12020-018-1592-6

Kruljac, I., et al. (2018) 'A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms', Endocrine, 60(3), str. 395-406. doi: 10.1007/s12020-018-1592-6

Kruljac I, Vurnek I, Maasberg S, Kust D, Blaslov K, Ladika Davidović B, i sur.. A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms. Endocrine [Internet]. 06.2018. [pristupljeno 11.04.2024.];60(3):395-406. doi: 10.1007/s12020-018-1592-6

I. Kruljac, et al., "A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms", Endocrine, vol. 60, br. 3, str. 395-406, Lipanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:826938. [Citirano: 11.04.2024.]

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Naslov (engleski)A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
AutorIvan Kruljac
AutorIvan Vurnek
AutorSebastian Maasberg
AutorDavor Kust
AutorKristina Blaslov
AutorBlaženka Ladika Davidović
AutorMario Štefanović
AutorAlma Demirović
AutorAlen Bišćanin
AutorJakša Filipović-Čugura
AutorJasmina Marić Brozić
AutorUlrich-Frank Pape
AutorMilan Vrkljan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Chromogranin A (CgA) is a valuable biomarker for detection and follow-up of patients with neuroendocrine neoplasms (NENs). However, various comorbidities may influence serum CgA, which decreases its diagnostic accuracy. We aimed to investigate which laboratory parameters are independently associated with increased CgA in real-life setting and to develop a scoring system, which could improve the diagnostic accuracy of CgA in detecting patients with NENs. ----- METHODS: This retrospective study included 55 treatment naïve patients with NENs and160 patients with various comorbidities but without NEN (nonNENs). Scoring system (CgA-score) was developed based on z-scores obtained from receiver operating curve analysis for each parameter that was associated with elevated serum CgA in nonNENs. ----- RESULTS: CgA correlated positively with serum BUN, creatinine, α2-globulin, red-cell distribution width, erythrocyte sedimentation rate, plasma glucose and correlated inversely with hemoglobin, thrombocytes and serum albumin. Serum CgA was also associated with the presence of chronic renal failure, arterial hypertension and diabetes and the use of PPI. In the entire study population, CgA showed an area under the curve of 0.656. Aforementioned parameters were used to develop a CgA-score. In a cohort of patients with CgA-score <12.0 (N = 87), serum CgA >156.5 ng/ml had 77.8% sensitivity and 91.5% specificity for detecting NENs (AUC 0.841, 95% CI 0.713-0.969, P < 0.001). Serum CgA had no diagnostic value in detecting NENs in patients with CgA-score >12.0 (AUC 0.554, 95% CI 0.405-0.702, P = 0.430). ----- CONCLUSIONS: CgA-score encompasses a wide range of comorbidities and represents a promising tool that could improve diagnostic performance of CgA in everyday clinical practice.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEndocrine
Brojčani podacivol. 60, br. 3, str. 395-406
p-ISSN1355-008X
DOIhttps://doi.org/10.1007/s12020-018-1592-6
URN:NBNurn:nbn:hr:105:826938
Datum objave publikacije2018-06
URL dokumentahttp://doi.org/10.1007/s12020-018-1592-6
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:14:08