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Leptin/adiponectin ratio in overweight patients – gender differences
Diabetes & Vascular Disease Research, 15 (2018), 3; 260-262. https://doi.org/doi:10.1177/1479164117752491
Selthofer-Relatić, Kristina; Radić, R.; Stupin, A.; Šišljagić, V.; Bošnjak, I.; Bulj, Nikola; Selthofer, R.; Delić Brkljačić, Diana

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Selthofer Relatić, K., Radić, R., Stupin, A., Šišljagić, V., Bošnjak, I., Bulj, N. ... Delić Brkljačić, D. (2018). Leptin/adiponectin ratio in overweight patients – gender differences. Diabetes & Vascular Disease Research, 15. (3), 260-262. doi: doi:10.1177/1479164117752491

Selthofer Relatić, Kristina, et al. "Leptin/adiponectin ratio in overweight patients – gender differences." Diabetes & Vascular Disease Research, vol. 15, br. 3, 2018, str. 260-262. https://doi.org/doi:10.1177/1479164117752491

Selthofer Relatić, Kristina, R. Radić, A. Stupin, V. Šišljagić, I. Bošnjak, Nikola Bulj, R. Selthofer i Diana Delić Brkljačić. "Leptin/adiponectin ratio in overweight patients – gender differences." Diabetes & Vascular Disease Research 15, br. 3 (2018): 260-262. https://doi.org/doi:10.1177/1479164117752491

Selthofer Relatić, K., et al. (2018) 'Leptin/adiponectin ratio in overweight patients – gender differences', Diabetes & Vascular Disease Research, 15(3), str. 260-262. doi: doi:10.1177/1479164117752491

Selthofer Relatić K, Radić R, Stupin A, Šišljagić V, Bošnjak I, Bulj N, i sur.. Leptin/adiponectin ratio in overweight patients – gender differences. Diabetes & Vascular Disease Research [Internet]. 15.05.2018. [pristupljeno 02.05.2024.];15(3):260-262. doi: doi:10.1177/1479164117752491

K. Selthofer Relatić, et al., "Leptin/adiponectin ratio in overweight patients – gender differences", Diabetes & Vascular Disease Research, vol. 15, br. 3, str. 260-262, Svibanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:537715. [Citirano: 02.05.2024.]

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Naslov (engleski)Leptin/adiponectin ratio in overweight patients – gender differences
AutorKristina Selthofer-Relatić
AutorR. Radić
AutorA. Stupin
AutorV. Šišljagić
AutorI. Bošnjak
AutorNikola Bulj
AutorR. Selthofer
AutorDiana Delić Brkljačić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
OBJECTIVE: Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obese patients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. ----- METHOD: The study included 80 adult males and females, overweight, non-diabetic patients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a radioimmunoassay test and total adiponectin levels with enzyme-linked immunosorbent assay. Leptin/adiponectin ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. ----- RESULTS: Differences between leptin, adiponectin serum levels and leptin/adiponectin ratios are presented in overweight persons, where females have a significantly higher leptin/adiponectin ratio than men ( p < 0.001). In men, the leptin/adiponectin ratio showed a positive correlation with total cholesterol levels ( p = 0.011), low-density lipoprotein ( p = 0.013) and triglycerides ( p = 0.032). In females, the leptin/adiponectin ratio correlated with anthropometric parameters of visceral obesity: waist circumference ( p = 0.001) and waist-to-hip ratio ( p = 0.025). ----- CONCLUSION: The leptin/adiponectin ratio could represent an atherosclerotic risk marker of the early stage of obesity. Gender plays a significant role in pathophysiological changes, with different clinical manifestations, where sex hormones have a crucial effect on neurohumoral adipose tissue activity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDiabetes & Vascular Disease Research
Brojčani podacivol. 15, br. 3, str. 260-262
p-ISSN1479-1641
DOIhttps://doi.org/doi:10.1177/1479164117752491
URN:NBNurn:nbn:hr:105:537715
Datum objave publikacije2018-05-15
URL dokumentahttp://doi.org/10.1177/1479164117752491
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:14:57